TY - JOUR
T1 - Blood group O alleles in Native Americans
T2 - Implications in the peopling of the Americas
AU - Estrada-Mena, Benito
AU - Estrada, F. Javier
AU - Ulloa-Arvizu, Raúl
AU - Guido, Miriam
AU - Méndez, Rocío
AU - Coral, Ramón
AU - Canto, Thelma
AU - Granados, Julio
AU - Rubí-Castellanos, Rodrigo
AU - Rangel-Villalobos, Héctor
AU - García-Carrancá, Alejandro
PY - 2010/5
Y1 - 2010/5
N2 - All major ABO blood alleles are found in most populations worldwide, whereas the majority of Native Americans are nearly exclusively in the O group. O allele molecular characterization could aid in elucidating the possible causes of group O predominance in Native American populations. In this work, we studied exon 6 and 7 sequence diversity in 180 O blood group individuals from four different Mesoamerican populations. Additionally, a comparative analysis of genetic diversity and population structure including South American populations was performed. Results revealed no significant differences among Mesoamerican and South American groups, but showed significant differences within population groups attributable to previously detected differences in genetic drift and founder effects throughout the American continent. Interestingly, in all American populations, the same set of haplotypes O1, O1v, and O1v(G542A) was present, suggesting the following: (1) that they constitute the main genetic pool of the founding population of the Americas and (2) that they derive from the same ancestral source, partially supporting the single founding population hypothesis. In addition, the consistent and restricted presence of the G542A mutation in Native Americans compared to worldwide populations allows it to be employed as an Ancestry informative marker (AIM). Present knowledge of the peopling of the Americas allows the prediction of the way in which the G542A mutation could have emerged in Beringia, probably during the differentiation process of Asian lineages that gave rise to the founding population of the continent. Am J Phys Anthropol 142:85-94, 2010.
AB - All major ABO blood alleles are found in most populations worldwide, whereas the majority of Native Americans are nearly exclusively in the O group. O allele molecular characterization could aid in elucidating the possible causes of group O predominance in Native American populations. In this work, we studied exon 6 and 7 sequence diversity in 180 O blood group individuals from four different Mesoamerican populations. Additionally, a comparative analysis of genetic diversity and population structure including South American populations was performed. Results revealed no significant differences among Mesoamerican and South American groups, but showed significant differences within population groups attributable to previously detected differences in genetic drift and founder effects throughout the American continent. Interestingly, in all American populations, the same set of haplotypes O1, O1v, and O1v(G542A) was present, suggesting the following: (1) that they constitute the main genetic pool of the founding population of the Americas and (2) that they derive from the same ancestral source, partially supporting the single founding population hypothesis. In addition, the consistent and restricted presence of the G542A mutation in Native Americans compared to worldwide populations allows it to be employed as an Ancestry informative marker (AIM). Present knowledge of the peopling of the Americas allows the prediction of the way in which the G542A mutation could have emerged in Beringia, probably during the differentiation process of Asian lineages that gave rise to the founding population of the continent. Am J Phys Anthropol 142:85-94, 2010.
KW - ABO
KW - Americas peopling
KW - Blood groups
KW - Founder effect
KW - Genetic drift
KW - Native American populations
UR - http://www.scopus.com/inward/record.url?scp=77950857102&partnerID=8YFLogxK
U2 - 10.1002/ajpa.21204
DO - 10.1002/ajpa.21204
M3 - Artículo
C2 - 19862808
SN - 0002-9483
VL - 142
SP - 85
EP - 94
JO - American Journal of Physical Anthropology
JF - American Journal of Physical Anthropology
IS - 1
ER -