TY - JOUR
T1 - Behavioural actions of two new 1-N substituted analogues of melatonin
AU - Bustamante-García, Ruth
AU - Naranjo-Rodríguez, Elia B.
AU - Lira-Rocha, Alfonso S.
AU - Ortiz-Osornio, Alejandro
AU - Picazo, Ofir
N1 - Funding Information:
We are grateful to M.V.Z. Atonatiu E. Gómez Martínez for his help in the management of animals. This study was supported by CONACYT No. 175952 , COFAA and SIP-IPN .
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Melatonin has been mainly used for alleviating some disorders related with insomnia and circadian rhythmicity. The use of this hormone has been limited, among others, due to its short half-life and instability. This study reports some behavioural actions of two new melatonin analogues that incorporate a phenyl or a benzoyl group at the nitrogen atom of the melatonin molecule. Although diazepam was about 10 times more potent than either of the melatonin analogues, results show that in general these last display better anxiolytic, anticonvulsant and sedative actions than the original molecule.
AB - Melatonin has been mainly used for alleviating some disorders related with insomnia and circadian rhythmicity. The use of this hormone has been limited, among others, due to its short half-life and instability. This study reports some behavioural actions of two new melatonin analogues that incorporate a phenyl or a benzoyl group at the nitrogen atom of the melatonin molecule. Although diazepam was about 10 times more potent than either of the melatonin analogues, results show that in general these last display better anxiolytic, anticonvulsant and sedative actions than the original molecule.
KW - 1-N melatonin analogues
KW - Anticonvulsant
KW - Anxiolytic
KW - Melatonin
KW - Sedative
UR - http://www.scopus.com/inward/record.url?scp=84866280253&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2012.08.045
DO - 10.1016/j.bbr.2012.08.045
M3 - Artículo
C2 - 22960257
SN - 0166-4328
VL - 236
SP - 148
EP - 156
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -