According to the high consumption of the mixture of B vitamins and diclofenac in several countries, this combination has constituted a frequently used option in pain therapy from inflammatory origin. Although the evidence obtained from inflammatory pain animal models has shown the existence of analgesic synergy between diclofenac and the B vitamins mixture, the corresponding clinical evidence is scarce. A double-blind, randomized clinical trial study was designed to characterize the analgesic effect and safety of diclofenac and B vitamins against diclofenac alone in patients with severe osteoarthritis. Forty eight patients programmed to total knee arthroplasty with a pain level ≥7 in a 1-10 cm visual analogue scale were allocated to receive a single intramuscular injection of sodium diclofenac (75 mg) alone or combined with thiamine (100 mg), pyridoxine (100 mg) and cyanocobalamin (5 mg), and the pain level was evaluated during 12 h post-injection. Diclofenac+B vitamins mixture showed a superior analgesic effect during the assessed period and also a better assessment of the pain relief perception by patients than diclofenac alone. This study constitutes a clinical support on the improvement of the analgesic effect of diclofenac by B vitamins in patients with osteoarthritis programmed to total knee arthroplasty, as a clinical model of inflammatory pain. © 2013 Georg Thieme Verlag KG Stuttgart · New York.
Magaña-Villa, M. C., Rocha-González, H. I., Fernández Del Valle-Laisequilla, C., Granados-Soto, V., Rodríguez-Silverio, J., Flores-Murrieta, F. J., Carrasco-Portugal, M. C., & Reyes-García, J. G. (2013). B-vitamin mixture improves the analgesic effect of diclofenac in patients with osteoarthritis: A double blind study. Drug Research, 289-292. https://doi.org/10.1055/s-0033-1334963