TY - JOUR
T1 - B-vitamin mixture improves the analgesic effect of diclofenac in patients with osteoarthritis
T2 - A double blind study
AU - Magaña-Villa, M. C.
AU - Rocha-González, H. I.
AU - Fernández Del Valle-Laisequilla, C.
AU - Granados-Soto, V.
AU - Rodríguez-Silverio, J.
AU - Flores-Murrieta, F. J.
AU - Carrasco-Portugal, M. C.
AU - Reyes-García, J. G.
PY - 2013/6
Y1 - 2013/6
N2 - According to the high consumption of the mixture of B vitamins and diclofenac in several countries, this combination has constituted a frequently used option in pain therapy from inflammatory origin. Although the evidence obtained from inflammatory pain animal models has shown the existence of analgesic synergy between diclofenac and the B vitamins mixture, the corresponding clinical evidence is scarce. A double-blind, randomized clinical trial study was designed to characterize the analgesic effect and safety of diclofenac and B vitamins against diclofenac alone in patients with severe osteoarthritis. Forty eight patients programmed to total knee arthroplasty with a pain level ≥7 in a 1-10 cm visual analogue scale were allocated to receive a single intramuscular injection of sodium diclofenac (75 mg) alone or combined with thiamine (100 mg), pyridoxine (100 mg) and cyanocobalamin (5 mg), and the pain level was evaluated during 12 h post-injection. Diclofenac+B vitamins mixture showed a superior analgesic effect during the assessed period and also a better assessment of the pain relief perception by patients than diclofenac alone. This study constitutes a clinical support on the improvement of the analgesic effect of diclofenac by B vitamins in patients with osteoarthritis programmed to total knee arthroplasty, as a clinical model of inflammatory pain.
AB - According to the high consumption of the mixture of B vitamins and diclofenac in several countries, this combination has constituted a frequently used option in pain therapy from inflammatory origin. Although the evidence obtained from inflammatory pain animal models has shown the existence of analgesic synergy between diclofenac and the B vitamins mixture, the corresponding clinical evidence is scarce. A double-blind, randomized clinical trial study was designed to characterize the analgesic effect and safety of diclofenac and B vitamins against diclofenac alone in patients with severe osteoarthritis. Forty eight patients programmed to total knee arthroplasty with a pain level ≥7 in a 1-10 cm visual analogue scale were allocated to receive a single intramuscular injection of sodium diclofenac (75 mg) alone or combined with thiamine (100 mg), pyridoxine (100 mg) and cyanocobalamin (5 mg), and the pain level was evaluated during 12 h post-injection. Diclofenac+B vitamins mixture showed a superior analgesic effect during the assessed period and also a better assessment of the pain relief perception by patients than diclofenac alone. This study constitutes a clinical support on the improvement of the analgesic effect of diclofenac by B vitamins in patients with osteoarthritis programmed to total knee arthroplasty, as a clinical model of inflammatory pain.
KW - B vitamins
KW - analgesia
KW - diclofenac
KW - inflammatory pain
KW - osteoarthritis
UR - http://www.scopus.com/inward/record.url?scp=84879469434&partnerID=8YFLogxK
U2 - 10.1055/s-0033-1334963
DO - 10.1055/s-0033-1334963
M3 - Artículo
C2 - 23526240
SN - 2194-9379
VL - 63
SP - 289
EP - 292
JO - Drug Research
JF - Drug Research
IS - 6
ER -