TY - JOUR
T1 - Autophagic and apoptotic pathways as targets for chemotherapy in glioblastoma
AU - Trejo-Solís, Cristina
AU - Serrano-Garcia, Norma
AU - Escamilla-Ramírez, Ángel
AU - Castillo-Rodríguez, Rosa A.
AU - Jimenez-Farfan, Dolores
AU - Palencia, Guadalupe
AU - Calvillo, Minerva
AU - Alvarez-Lemus, Mayra A.
AU - Flores-Nájera, Athenea
AU - Cruz-Salgado, Arturo
AU - Sotelo, Julio
N1 - Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018/12
Y1 - 2018/12
N2 - Glioblastoma multiforme is the most malignant and aggressive type of brain tumor, with a mean life expectancy of less than 15 months. This is due in part to the high resistance to apoptosis and moderate resistant to autophagic cell death in glioblastoma cells, and to the poor therapeutic response to conventional therapies. Autophagic cell death represents an alternative mechanism to overcome the resistance of glioblastoma to pro-apoptosis-related therapies. Nevertheless, apoptosis induction plays a major conceptual role in several experimental studies to develop novel therapies against brain tumors. In this review, we outline the different components of the apoptotic and autophagic pathways and explore the mechanisms of resistance to these cell death pathways in glioblastoma cells. Finally, we discuss drugs with clinical and preclinical use that interfere with the mechanisms of survival, proliferation, angiogenesis, migration, invasion, and cell death of malignant cells, favoring the induction of apoptosis and autophagy, or the inhibition of the latter leading to cell death, as well as their therapeutic potential in glioma, and examine new perspectives in this promising research field.
AB - Glioblastoma multiforme is the most malignant and aggressive type of brain tumor, with a mean life expectancy of less than 15 months. This is due in part to the high resistance to apoptosis and moderate resistant to autophagic cell death in glioblastoma cells, and to the poor therapeutic response to conventional therapies. Autophagic cell death represents an alternative mechanism to overcome the resistance of glioblastoma to pro-apoptosis-related therapies. Nevertheless, apoptosis induction plays a major conceptual role in several experimental studies to develop novel therapies against brain tumors. In this review, we outline the different components of the apoptotic and autophagic pathways and explore the mechanisms of resistance to these cell death pathways in glioblastoma cells. Finally, we discuss drugs with clinical and preclinical use that interfere with the mechanisms of survival, proliferation, angiogenesis, migration, invasion, and cell death of malignant cells, favoring the induction of apoptosis and autophagy, or the inhibition of the latter leading to cell death, as well as their therapeutic potential in glioma, and examine new perspectives in this promising research field.
KW - Apoptosis
KW - Autophagia
KW - Chemotherapy
KW - Glioblastoma
KW - Signaling pathways
KW - Therapeutic targets
UR - http://www.scopus.com/inward/record.url?scp=85057531643&partnerID=8YFLogxK
U2 - 10.3390/ijms19123773
DO - 10.3390/ijms19123773
M3 - Artículo de revisión
C2 - 30486451
AN - SCOPUS:85057531643
SN - 1661-6596
VL - 19
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 12
M1 - 3773
ER -