TY - JOUR
T1 - Autoantibodies against the fibrinolytic receptor, annexin A2, in cerebral venous thrombosis
AU - Cesarman-Maus, Gabriela
AU - Cantú-Brito, Carlos
AU - Barinagarrementeria, Fernando
AU - Villa, Rosario
AU - Reyes, Elba
AU - Sanchez-Guerrero, Jorge
AU - Hajjar, Katherine A.
AU - Latorre, Ethel Garcia
PY - 2011/2
Y1 - 2011/2
N2 - Background and Purpose- Cerebral venous thrombosis (CVT) may be a manifestation of underlying autoimmune disease. Antibodies against annexin A2 (anti-A2Ab) coincide with antiphospholipid syndrome, in which antiphospholipid antibodies (aPLA) are associated with thrombosis in any vascular bed. Annexin A2, a profibrinolytic receptor and binding site for β2-glycoprotein-I, the main target for aPLA, is highly expressed on cerebral endothelium. Here we evaluate the prevalence of anti-A2Ab in CVT. Methods- Forty individuals with objectively documented CVT (33 women and 7 men) and 145 healthy controls were prospectively studied for hereditary and acquired prothrombotic risk factors, classical aPLA, and anti-A2Ab. Results- One or more prothrombotic risk factors were found in 85% of CVT subjects, (pregnancy/puerperium in 57.5%, classical aPLA in 22.5%, and hereditary procoagulant risk factors in 17.5%). Anti-A2Ab (titer >3 SD) were significantly more prevalent in patients with CVT (12.5%) than in healthy individuals (2.1%, P<0.01, OR, 5.9). Conclusions- Anti-A2Ab are significantly associated with CVT and may define a subset of individuals with immune-mediated cerebral thrombosis.
AB - Background and Purpose- Cerebral venous thrombosis (CVT) may be a manifestation of underlying autoimmune disease. Antibodies against annexin A2 (anti-A2Ab) coincide with antiphospholipid syndrome, in which antiphospholipid antibodies (aPLA) are associated with thrombosis in any vascular bed. Annexin A2, a profibrinolytic receptor and binding site for β2-glycoprotein-I, the main target for aPLA, is highly expressed on cerebral endothelium. Here we evaluate the prevalence of anti-A2Ab in CVT. Methods- Forty individuals with objectively documented CVT (33 women and 7 men) and 145 healthy controls were prospectively studied for hereditary and acquired prothrombotic risk factors, classical aPLA, and anti-A2Ab. Results- One or more prothrombotic risk factors were found in 85% of CVT subjects, (pregnancy/puerperium in 57.5%, classical aPLA in 22.5%, and hereditary procoagulant risk factors in 17.5%). Anti-A2Ab (titer >3 SD) were significantly more prevalent in patients with CVT (12.5%) than in healthy individuals (2.1%, P<0.01, OR, 5.9). Conclusions- Anti-A2Ab are significantly associated with CVT and may define a subset of individuals with immune-mediated cerebral thrombosis.
KW - annexin A2
KW - antiphospholipid syndrome
KW - cerebral venous thrombosis
KW - thrombophilia
UR - http://www.scopus.com/inward/record.url?scp=79251640440&partnerID=8YFLogxK
U2 - 10.1161/STROKEAHA.110.592121
DO - 10.1161/STROKEAHA.110.592121
M3 - Artículo
C2 - 21193750
SN - 0039-2499
VL - 42
SP - 501
EP - 503
JO - Stroke
JF - Stroke
IS - 2
ER -