TY - JOUR
T1 - Asymmetric Reactions of N-Phosphonyl/Phosphoryl Imines
AU - Ray, Devalina
AU - Majee, Suman
AU - Yadav, Ram Naresh
AU - Banik, Bimal Krishna
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/4
Y1 - 2023/4
N2 - The asymmetric reactions of imines continued to attract the attention of the scientific community for decades. However, the stereoselective reactions of N-phosphonyl/phosphoryl imines remained less explored as compared to other N-substituted imines. The chiral auxiliary-based asymmetric-induction strategy with N-phosphonyl imines could effectively generate enantio- and diastereomeric amine, α,β-diamine, and other products through various reactions. On the other hand, the asymmetric approach for the generation of chirality through the utilization of optically active ligands, along with metal catalysts, could be successfully implemented on N-phosphonyl/phosphoryl imines to access numerous synthetically challenging chiral amine scaffolds. The current review critically summarizes and reveals the literature precedence of more than a decade to highlight the major achievements existing to date that can display a clear picture of advancement as well drawbacks in this area.
AB - The asymmetric reactions of imines continued to attract the attention of the scientific community for decades. However, the stereoselective reactions of N-phosphonyl/phosphoryl imines remained less explored as compared to other N-substituted imines. The chiral auxiliary-based asymmetric-induction strategy with N-phosphonyl imines could effectively generate enantio- and diastereomeric amine, α,β-diamine, and other products through various reactions. On the other hand, the asymmetric approach for the generation of chirality through the utilization of optically active ligands, along with metal catalysts, could be successfully implemented on N-phosphonyl/phosphoryl imines to access numerous synthetically challenging chiral amine scaffolds. The current review critically summarizes and reveals the literature precedence of more than a decade to highlight the major achievements existing to date that can display a clear picture of advancement as well drawbacks in this area.
KW - N-phosphoryl/phosphonyl imines
KW - asymmetric synthesis
KW - chiral catalysis
KW - ligands
KW - stereoselective
UR - http://www.scopus.com/inward/record.url?scp=85156091894&partnerID=8YFLogxK
U2 - 10.3390/molecules28083524
DO - 10.3390/molecules28083524
M3 - Artículo de revisión
C2 - 37110758
AN - SCOPUS:85156091894
SN - 1420-3049
VL - 28
JO - Molecules
JF - Molecules
IS - 8
M1 - 3524
ER -