TY - JOUR
T1 - Association of total and pancreatic serum amylase enzymatic activity with insulin resistance and the glucose and insulin responses to oral starch test in Mexican children
AU - Locia-Morales, Daniel
AU - Vázquez-Moreno, Miguel
AU - González-Dzib, Roxana
AU - Domínguez-Hernández, Carmen
AU - Pérez-Herrera, Aleyda
AU - Robles-Ramírez, Roberto J.
AU - Rocha-Cruz, Alberto
AU - Meyre, David
AU - Flores-Alfaro, Eugenia
AU - Cruz, Miguel
N1 - Publisher Copyright:
© 2022 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
PY - 2022/12
Y1 - 2022/12
N2 - Background/Objectives: Little is known about the effect of serum amylase enzymatic activity on glucose metabolism. We investigated the association of serum amylase enzymatic activity with fasting plasma glucose, insulin resistance (IR), and the plasma glucose and insulin response to an oral starch test (OST) in Mexican children. Methods: Anthropometric data, glucose and insulin levels, and the serum enzymatic activity of total (AMYt), salivary (AMY1), and pancreatic (AMY2) amylase were analysed in 764 children (Nnormal weight = 427/Nobesity = 337). After categorization into low (LA) and high (HA) AMYt, an OST with commercial white bread was performed in 39 children (Nnormal weight = 17/Nobesity = 22). Results: A positive association between serum enzymatic activity of AMY2 and IR was observed in children with obesity (p = 0.018). Children with normal weight had lower plasma glucose and insulin response to OST than children with obesity (Pglucose = 4.1 × 10−12; Pinsulin = 2.1 × 10−15). Compared with the LA group, children with HA showed lower plasma glucose and insulin response to OST (Pglucose ≤ 0.040; Pinsulin ≤ 0.015). Conclusion: Our results suggest that AMY2 is positively associated with IR. A high level of AMYt is related to lower glucose and insulin responses to OST in Mexican children, regardless of their weight status.
AB - Background/Objectives: Little is known about the effect of serum amylase enzymatic activity on glucose metabolism. We investigated the association of serum amylase enzymatic activity with fasting plasma glucose, insulin resistance (IR), and the plasma glucose and insulin response to an oral starch test (OST) in Mexican children. Methods: Anthropometric data, glucose and insulin levels, and the serum enzymatic activity of total (AMYt), salivary (AMY1), and pancreatic (AMY2) amylase were analysed in 764 children (Nnormal weight = 427/Nobesity = 337). After categorization into low (LA) and high (HA) AMYt, an OST with commercial white bread was performed in 39 children (Nnormal weight = 17/Nobesity = 22). Results: A positive association between serum enzymatic activity of AMY2 and IR was observed in children with obesity (p = 0.018). Children with normal weight had lower plasma glucose and insulin response to OST than children with obesity (Pglucose = 4.1 × 10−12; Pinsulin = 2.1 × 10−15). Compared with the LA group, children with HA showed lower plasma glucose and insulin response to OST (Pglucose ≤ 0.040; Pinsulin ≤ 0.015). Conclusion: Our results suggest that AMY2 is positively associated with IR. A high level of AMYt is related to lower glucose and insulin responses to OST in Mexican children, regardless of their weight status.
KW - Mexican children
KW - insulin resistance
KW - oral starch test
KW - serum amylase
UR - http://www.scopus.com/inward/record.url?scp=85136991349&partnerID=8YFLogxK
U2 - 10.1111/ijpo.12965
DO - 10.1111/ijpo.12965
M3 - Artículo
C2 - 36350201
AN - SCOPUS:85136991349
SN - 2047-6302
VL - 17
JO - Pediatric Obesity
JF - Pediatric Obesity
IS - 12
M1 - e12965
ER -
