TY - JOUR
T1 - Association of the 5HTTLPR Polymorphism with Obesity in Mexican Women with High Native American Ancestry
AU - Galaviz-Hernández, Carlos
AU - Lazalde-Ramos, Blanca P.
AU - Martínez-Cortés, Gabriela
AU - Rangel-Villalobos, Héctor
AU - Martínez-Aguilar, Gerardo
AU - Leal-Ugarte, Evelia
AU - Peralta-Leal, Valeria
AU - González-Rentería, Siblie
AU - Rodríguez-Moran, Martha
AU - Jaquez-Chairez, Francia
AU - Guerrero-Romero, Fernando
AU - Sosa-Macías, Martha
N1 - Publisher Copyright:
© Copyright 2020, Mary Ann Liebert, Inc., publishers 2020.
PY - 2020/11
Y1 - 2020/11
N2 - Aims: The 5HTT gene has been associated with obesity; this study aimed to determine the association between L-and S-Alleles at the 5HTTLPR polymorphism with obesity in indigenous Mexican populations. Materials and Methods: A total of 362 individuals, 289 belonging to eight Native American (NA) groups; 40 Mexican mestizos; and 33 Caucasian Mennonites were enrolled in a cross-sectional study. High (≥90%) and low (<90%) NA ancestry was molecularly determined. A body mass index >30 kg/m2 was considered as obese. The L-and S-Alleles of the 5HTTLPR locus were identified by PCR; the association between alleles and obesity was performed by logistic regression analysis. Results: A significantly lower prevalence of obesity (35%) was observed in participants from communities with high NA ancestry (p < 0.005). Under a dominant heritance model the L-Allele was associated with obesity in women with high NA ancestry (odds ratio [OR] 7.27; 95% confidence interval [CI] 1.6-32.5; p = 0.009) but not in women with low NA ancestry (OR 0.83; 95% CI 0.3-2.2; p = 0.71); no association was observed in men. Conclusion: Our results suggest that the 5HTTLPR L-Allele is a risk factor for developing obesity in Mexican women with high NA ancestry (≥90%).
AB - Aims: The 5HTT gene has been associated with obesity; this study aimed to determine the association between L-and S-Alleles at the 5HTTLPR polymorphism with obesity in indigenous Mexican populations. Materials and Methods: A total of 362 individuals, 289 belonging to eight Native American (NA) groups; 40 Mexican mestizos; and 33 Caucasian Mennonites were enrolled in a cross-sectional study. High (≥90%) and low (<90%) NA ancestry was molecularly determined. A body mass index >30 kg/m2 was considered as obese. The L-and S-Alleles of the 5HTTLPR locus were identified by PCR; the association between alleles and obesity was performed by logistic regression analysis. Results: A significantly lower prevalence of obesity (35%) was observed in participants from communities with high NA ancestry (p < 0.005). Under a dominant heritance model the L-Allele was associated with obesity in women with high NA ancestry (odds ratio [OR] 7.27; 95% confidence interval [CI] 1.6-32.5; p = 0.009) but not in women with low NA ancestry (OR 0.83; 95% CI 0.3-2.2; p = 0.71); no association was observed in men. Conclusion: Our results suggest that the 5HTTLPR L-Allele is a risk factor for developing obesity in Mexican women with high NA ancestry (≥90%).
KW - ethnic groups
KW - genotype
KW - obesity
KW - serotonin
KW - transporter proteins
UR - http://www.scopus.com/inward/record.url?scp=85096202773&partnerID=8YFLogxK
U2 - 10.1089/gtmb.2020.0068
DO - 10.1089/gtmb.2020.0068
M3 - Artículo
C2 - 33050716
AN - SCOPUS:85096202773
SN - 1945-0265
VL - 24
SP - 754
EP - 758
JO - Genetic Testing and Molecular Biomarkers
JF - Genetic Testing and Molecular Biomarkers
IS - 11
ER -