TY - JOUR
T1 - Association of AMY1A/AMY2A copy numbers and AMY1/AMY2 serum enzymatic activity with obesity in Mexican children
AU - National Obesity Network Mexico
AU - Vázquez-Moreno, Miguel
AU - Mejía-Benítez, Aurora
AU - Sharma, Tanmay
AU - Peralta-Romero, Jesús
AU - Locia-Morales, Daniel
AU - Klünder-Klünder, Miguel
AU - Álvarez-Villaseñor, Andrea S.
AU - Acosta, Kelly G.
AU - Flores-Torrecillas, Raquel
AU - Flores-Osuna, Uriel
AU - García-Avilés, Mariell G.
AU - del González-Dzib, Roxana S.
AU - Gameros-Gardea, René A.
AU - Pizano-Zárate, María L.
AU - del Romero-Figueroa, María S.
AU - Núñez-Hernández, Jorge A.
AU - de León-Camacho, Verónica
AU - Karam-Araujo, Roberto
AU - Corona-Salazar, Perla
AU - Valladares-Salgado, Adán
AU - Suarez-Sánchez, Fernando
AU - Gómez-Zamudio, Jaime
AU - Flores-Alfaro, Eugenia
AU - Sosa-Bustamante, Gloria P.
AU - Reyes-Hernández, Arturo
AU - Peralta-Cortázar, Catalina
AU - Martínez-Morales, Emmanuel G.
AU - Díaz de León-Morales, Luz V.
AU - del González-González, Irma L.C.
AU - Reyes-Sosa, Arturo M.
AU - Lazcano-Bautista, Sonia
AU - Martínez-Chávez, Marcela
AU - González-Serrano, Fátima D.
AU - Rodríguez-Alfaro, Alma N.
AU - Murillo-Ortiz, Blanca O.
AU - Arteaga-Alcaraz, María G.
AU - García-Silva, Nandy
AU - Herrera-Lemus, Moisés
AU - Gómez-Arteaga, Gress M.
AU - Gómez-García, Anel
AU - Urbina-Treviño, Martha V.
AU - Villalpando-Sánchez, Diana C.
AU - Álvarez-Aguilar, Cleto
AU - Jiménez-Arredondo, Ramón E.
AU - Dávila-Rodríguez, Martha I.
AU - González-Salazar, Francisco
AU - de la Garza-Salinas, Laura H.
AU - Pérez-Herrera, Aleyda
AU - Méndez-Martínez, Socorro
AU - Martínez-Torres, Jorge
N1 - Publisher Copyright:
© 2020 World Obesity Federation
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Background: Mexican children are characterized by a high-starch intake diet and high prevalence of obesity. Objectives: To investigate the association of AMY1A/AMY2A copy numbers (CNs) and AMY1/AMY2 serum enzymatic activity with childhood obesity in up to 427 and 337 Mexican cases and controls. Methods: Anthropometric and dietary starch intake data were collected. CN of AMY1A/AMY2A and AMY1/AMY2 serum enzymatic activity were determined using droplet digital PCR (ddPCR) and enzymatic colorimetry, respectively. An individual participant level data meta-analysis of association between AMY1A CNVs and obesity was also performed. Results: A positive association between AMY1A/AMY2A CNs and their corresponding AMY1/AMY2 serum enzyme activity was observed in children with normal weight and obesity. The serum enzyme activity of AMY1 and AMY2 was negatively associated with childhood obesity risk, and the association was restricted to kids eating medium/high amount of starch (Pinteraction =.004). While no association between AMY1A and AMY2A CNs and childhood obesity was observed in our sample, we confirmed a significant association between AMY1A CN and obesity in a meta-analysis of 3100 Mexican children. Conclusions: Our data suggest that genetically determined salivary and pancreatic amylase activity can increase/decrease the risk of obesity in Mexican children, this effect being blunted by a low-starch diet.
AB - Background: Mexican children are characterized by a high-starch intake diet and high prevalence of obesity. Objectives: To investigate the association of AMY1A/AMY2A copy numbers (CNs) and AMY1/AMY2 serum enzymatic activity with childhood obesity in up to 427 and 337 Mexican cases and controls. Methods: Anthropometric and dietary starch intake data were collected. CN of AMY1A/AMY2A and AMY1/AMY2 serum enzymatic activity were determined using droplet digital PCR (ddPCR) and enzymatic colorimetry, respectively. An individual participant level data meta-analysis of association between AMY1A CNVs and obesity was also performed. Results: A positive association between AMY1A/AMY2A CNs and their corresponding AMY1/AMY2 serum enzyme activity was observed in children with normal weight and obesity. The serum enzyme activity of AMY1 and AMY2 was negatively associated with childhood obesity risk, and the association was restricted to kids eating medium/high amount of starch (Pinteraction =.004). While no association between AMY1A and AMY2A CNs and childhood obesity was observed in our sample, we confirmed a significant association between AMY1A CN and obesity in a meta-analysis of 3100 Mexican children. Conclusions: Our data suggest that genetically determined salivary and pancreatic amylase activity can increase/decrease the risk of obesity in Mexican children, this effect being blunted by a low-starch diet.
KW - Mexican population
KW - amylase
KW - childhood obesity
KW - copy-number variants
KW - dietary starch intake
KW - enzyme activity
UR - http://www.scopus.com/inward/record.url?scp=85083716433&partnerID=8YFLogxK
U2 - 10.1111/ijpo.12641
DO - 10.1111/ijpo.12641
M3 - Artículo
AN - SCOPUS:85083716433
SN - 2047-6302
VL - 15
JO - Pediatric Obesity
JF - Pediatric Obesity
IS - 8
M1 - e12641
ER -