Arsenic exposure and non-carcinogenic health effects

Macario Martínez-Castillo; Eliud A. García-Montalvo; Mónica G. Arellano-Mendoza; Luz del C. Sánchez-Peña; Luis E. Soria Jasso; Jeannett A. Izquierdo-Vega; Olga L. Valenzuela; Araceli Hernández-Zavala

doi:10.1177/09603271211045955

Arsenic exposure and non-carcinogenic health effects

Macario Martínez-Castillo, Eliud A. García-Montalvo, Mónica G. Arellano-Mendoza, Luz del C. Sánchez-Peña, Luis E. Soria Jasso, Jeannett A. Izquierdo-Vega, Olga L. Valenzuela, Araceli Hernández-Zavala

Escuela Superior de Medicina (ESM)

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Inorganic arsenic (iAs) exposure is a serious health problem that affects more than 140 million individuals worldwide, mainly, through contaminated drinking water. Acute iAs poisoning produces several symptoms such as nausea, vomiting, abdominal pain, and severe diarrhea, whereas prolonged iAs exposure increased the risk of several malignant disorders such as lung, urinary tract, and skin tumors. Another sensitive endpoint less described of chronic iAs exposure are the non-malignant health effects in hepatic, endocrine, renal, neurological, hematological, immune, and cardiovascular systems. The present review outlines epidemiology evidence and possible molecular mechanisms associated with iAs-toxicity in several non-carcinogenic disorders.

Original language	English
Pages (from-to)	S826-S850
Journal	Human and Experimental Toxicology
Volume	40
Issue number	12_suppl
DOIs	https://doi.org/10.1177/09603271211045955
State	Published - Dec 2021

Keywords

Neuropathy
immunosuppression
kidney
liver
pancreas
vascular effects

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10.1177/09603271211045955

Cite this

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title = "Arsenic exposure and non-carcinogenic health effects",

abstract = "Inorganic arsenic (iAs) exposure is a serious health problem that affects more than 140 million individuals worldwide, mainly, through contaminated drinking water. Acute iAs poisoning produces several symptoms such as nausea, vomiting, abdominal pain, and severe diarrhea, whereas prolonged iAs exposure increased the risk of several malignant disorders such as lung, urinary tract, and skin tumors. Another sensitive endpoint less described of chronic iAs exposure are the non-malignant health effects in hepatic, endocrine, renal, neurological, hematological, immune, and cardiovascular systems. The present review outlines epidemiology evidence and possible molecular mechanisms associated with iAs-toxicity in several non-carcinogenic disorders.",

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author = "Macario Mart{\'i}nez-Castillo and Garc{\'i}a-Montalvo, {Eliud A.} and Arellano-Mendoza, {M{\'o}nica G.} and S{\'a}nchez-Pe{\~n}a, {Luz del C.} and {Soria Jasso}, {Luis E.} and Izquierdo-Vega, {Jeannett A.} and Valenzuela, {Olga L.} and Araceli Hern{\'a}ndez-Zavala",

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doi = "10.1177/09603271211045955",

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T1 - Arsenic exposure and non-carcinogenic health effects

AU - Martínez-Castillo, Macario

AU - García-Montalvo, Eliud A.

AU - Arellano-Mendoza, Mónica G.

AU - Sánchez-Peña, Luz del C.

AU - Soria Jasso, Luis E.

AU - Izquierdo-Vega, Jeannett A.

AU - Valenzuela, Olga L.

AU - Hernández-Zavala, Araceli

N1 - Publisher Copyright: © The Author(s) 2021.

PY - 2021/12

Y1 - 2021/12

N2 - Inorganic arsenic (iAs) exposure is a serious health problem that affects more than 140 million individuals worldwide, mainly, through contaminated drinking water. Acute iAs poisoning produces several symptoms such as nausea, vomiting, abdominal pain, and severe diarrhea, whereas prolonged iAs exposure increased the risk of several malignant disorders such as lung, urinary tract, and skin tumors. Another sensitive endpoint less described of chronic iAs exposure are the non-malignant health effects in hepatic, endocrine, renal, neurological, hematological, immune, and cardiovascular systems. The present review outlines epidemiology evidence and possible molecular mechanisms associated with iAs-toxicity in several non-carcinogenic disorders.

AB - Inorganic arsenic (iAs) exposure is a serious health problem that affects more than 140 million individuals worldwide, mainly, through contaminated drinking water. Acute iAs poisoning produces several symptoms such as nausea, vomiting, abdominal pain, and severe diarrhea, whereas prolonged iAs exposure increased the risk of several malignant disorders such as lung, urinary tract, and skin tumors. Another sensitive endpoint less described of chronic iAs exposure are the non-malignant health effects in hepatic, endocrine, renal, neurological, hematological, immune, and cardiovascular systems. The present review outlines epidemiology evidence and possible molecular mechanisms associated with iAs-toxicity in several non-carcinogenic disorders.

KW - Neuropathy

KW - immunosuppression

KW - kidney

KW - liver

KW - pancreas

KW - vascular effects

UR - http://www.scopus.com/inward/record.url?scp=85116470930&partnerID=8YFLogxK

U2 - 10.1177/09603271211045955

DO - 10.1177/09603271211045955

M3 - Artículo

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AN - SCOPUS:85116470930

SN - 0960-3271

VL - 40

SP - S826-S850

JO - Human and Experimental Toxicology

JF - Human and Experimental Toxicology

IS - 12_suppl

ER -

Arsenic exposure and non-carcinogenic health effects

Abstract

Keywords

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