TY - JOUR
T1 - Arginase activity in patients with breast cancer
T2 - An analysis of plasma, tumors, and its relationship with the presence of the estrogen receptor
AU - Perez, Gabriel
AU - Olivares, Ivonne M.
AU - Rodriguez, Magdalena G.
AU - Ceballos, Guillermo M.
AU - Sanchez, Jose R.Garcia
PY - 2012/10
Y1 - 2012/10
N2 - Background: Breast cancer is an important cause of cancerrelated death in women. In this pathological condition, arginase plays a role by providing ornithine as a substrate for the biosynthesis of polyamines which are important in tumor progression. The aim of this work was to determine the arginase activity in the plasma and tumors of patients with breast cancer; also, we investigated the relationship between this activity and the presence of the estrogen receptor. Patients and Methods: We evaluated the plasma arginase activity levels in 80 women with breast cancer and 42 healthy control subjects. We also measured the arginase levels in 42 breast cancer biopsies and 42 control tissues. Results: The mean activity of arginase in plasma was higher in breast cancer patients (0.78 nM/min/mg protein ± 0.04; p = 0.001) than in healthy volunteers (0.53 nM/min/mg protein ± 0.04); however, this difference was indicative of patients in the advanced stages of the disease (n = 38, stage III; p < 0.0001). In addition, we did not find a relationship between the estrogen receptor and arginase activity. Conclusion: Our results show a higher arginase activity in the plasma of patients in the advanced stages of the disease, suggesting that arginase activity could serve as a possible biological marker of breast cancer progression.
AB - Background: Breast cancer is an important cause of cancerrelated death in women. In this pathological condition, arginase plays a role by providing ornithine as a substrate for the biosynthesis of polyamines which are important in tumor progression. The aim of this work was to determine the arginase activity in the plasma and tumors of patients with breast cancer; also, we investigated the relationship between this activity and the presence of the estrogen receptor. Patients and Methods: We evaluated the plasma arginase activity levels in 80 women with breast cancer and 42 healthy control subjects. We also measured the arginase levels in 42 breast cancer biopsies and 42 control tissues. Results: The mean activity of arginase in plasma was higher in breast cancer patients (0.78 nM/min/mg protein ± 0.04; p = 0.001) than in healthy volunteers (0.53 nM/min/mg protein ± 0.04); however, this difference was indicative of patients in the advanced stages of the disease (n = 38, stage III; p < 0.0001). In addition, we did not find a relationship between the estrogen receptor and arginase activity. Conclusion: Our results show a higher arginase activity in the plasma of patients in the advanced stages of the disease, suggesting that arginase activity could serve as a possible biological marker of breast cancer progression.
KW - Arginase
KW - Estrogen receptor
KW - Tumor
UR - http://www.scopus.com/inward/record.url?scp=84867259175&partnerID=8YFLogxK
U2 - 10.1159/000343005
DO - 10.1159/000343005
M3 - Artículo
C2 - 23038227
SN - 0378-584X
VL - 35
SP - 570
EP - 574
JO - Onkologie
JF - Onkologie
IS - 10
ER -