TY - JOUR
T1 - Anxiolytic-like effects of a new 1-N substituted analog of melatonin in pinealectomized rats
AU - Bustamante-García, R.
AU - Lira-Rocha, A. S.
AU - Espejo-González, O.
AU - Gómez-Martínez, A. E.
AU - Picazo, O.
N1 - Funding Information:
The authors thank Bruce Allan Larsen for reviewing the use of English in the manuscript. This study was partially supported by COFAA and SIP-IPN .
PY - 2014/6/3
Y1 - 2014/6/3
N2 - In spite of the wide variety of drugs available for treating anxiety, this disorder continues to represent a worldwide health problem that is classified within the first 10 causes of disability. Therefore, the search continues for new antianxiety agents, particularly those not related to benzodiazepines. Even though melatonin has been prescribed as an anxiolytic drug, its use is currently limited due to its short half-life and photo-sensitivity, among other disadvantages. The present study explores the antianxiety properties of a new 1-N substituted melatonin analog, M3C, in pinealectomized rats submitted to two behavioral tests (the cumulative burying behavior paradigm and the elevated plus-maze). Results from both tests show that M3C is effective as an anxiolytic-like agent, at doses lower than any other melatonin analog previously reported. The blocking of these actions by luzindole together with the available data suggests that the anxiolytic properties of M3C are mediated by MT1 and MT2 receptors.
AB - In spite of the wide variety of drugs available for treating anxiety, this disorder continues to represent a worldwide health problem that is classified within the first 10 causes of disability. Therefore, the search continues for new antianxiety agents, particularly those not related to benzodiazepines. Even though melatonin has been prescribed as an anxiolytic drug, its use is currently limited due to its short half-life and photo-sensitivity, among other disadvantages. The present study explores the antianxiety properties of a new 1-N substituted melatonin analog, M3C, in pinealectomized rats submitted to two behavioral tests (the cumulative burying behavior paradigm and the elevated plus-maze). Results from both tests show that M3C is effective as an anxiolytic-like agent, at doses lower than any other melatonin analog previously reported. The blocking of these actions by luzindole together with the available data suggests that the anxiolytic properties of M3C are mediated by MT1 and MT2 receptors.
KW - Anxiety
KW - Burying behavior
KW - Elevated plus-maze
KW - Luzindole
KW - Melatonin
KW - Pinealectomy
UR - http://www.scopus.com/inward/record.url?scp=84896699308&partnerID=8YFLogxK
U2 - 10.1016/j.pnpbp.2014.01.015
DO - 10.1016/j.pnpbp.2014.01.015
M3 - Artículo
C2 - 24495777
SN - 0278-5846
VL - 51
SP - 133
EP - 139
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
ER -