Antisecretory activity of plants used to treat gastrointestinal disorders in Mexico

Claudia Velázquez; Fernando Calzada; Javier Torres; Felipe González; Guillermo Ceballos

doi:10.1016/j.jep.2005.06.046

Antisecretory activity of plants used to treat gastrointestinal disorders in Mexico

Claudia Velázquez, Fernando Calzada, Javier Torres, Felipe González, Guillermo Ceballos

Escuela Superior de Medicina (ESM)

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Aqueous and methanolic extracts from 26 medicinal plants used in Mexico to treat gastrointestinal disorders were screened to evaluate their antisecretory activity on cholera toxin-induced intestinal secretion in rat jejunal loops model. Extracts were tested at a dose of 300 mg/kg. From 56 samples tested, both extracts from Chiranthodendron pentadactylon, Hippocratea excelsa and Ocimum basilicum were the most potent with inhibition values ranging from 68.0 to 87.6%. On the other hand, the methanolic extract of Geranium mexicanum (aerial parts) and the aqueous extract of Bocconia frutescens showed the highest activity with inhibition values of 93.4 and 86.0%, respectively. The results obtained in this study give some scientific support to the use of the Mexican medicinal plants employed for the treatment of gastrointestinal disorders such as diarrhea.

Original language	English
Pages (from-to)	66-70
Number of pages	5
Journal	Journal of Ethnopharmacology
Volume	103
Issue number	1
DOIs	https://doi.org/10.1016/j.jep.2005.06.046
State	Published - 3 Jan 2006

Keywords

Antisecretory activity
Aqueous extracts
Cholera toxin
Methanolic extracts
Mexican medicinal plants

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10.1016/j.jep.2005.06.046

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title = "Antisecretory activity of plants used to treat gastrointestinal disorders in Mexico",

abstract = "Aqueous and methanolic extracts from 26 medicinal plants used in Mexico to treat gastrointestinal disorders were screened to evaluate their antisecretory activity on cholera toxin-induced intestinal secretion in rat jejunal loops model. Extracts were tested at a dose of 300 mg/kg. From 56 samples tested, both extracts from Chiranthodendron pentadactylon, Hippocratea excelsa and Ocimum basilicum were the most potent with inhibition values ranging from 68.0 to 87.6%. On the other hand, the methanolic extract of Geranium mexicanum (aerial parts) and the aqueous extract of Bocconia frutescens showed the highest activity with inhibition values of 93.4 and 86.0%, respectively. The results obtained in this study give some scientific support to the use of the Mexican medicinal plants employed for the treatment of gastrointestinal disorders such as diarrhea.",

keywords = "Antisecretory activity, Aqueous extracts, Cholera toxin, Methanolic extracts, Mexican medicinal plants",

author = "Claudia Vel{\'a}zquez and Fernando Calzada and Javier Torres and Felipe Gonz{\'a}lez and Guillermo Ceballos",

note = "Funding Information: MS Abigail Aguilar, IMSS herbarium, for authentication of plant material and Antonio Cervantes. This study was supported by CONACyT (grant: 38030-M); IMSS-FOFOI (FP-2001-053).",

year = "2006",

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doi = "10.1016/j.jep.2005.06.046",

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T1 - Antisecretory activity of plants used to treat gastrointestinal disorders in Mexico

AU - Velázquez, Claudia

AU - Calzada, Fernando

AU - Torres, Javier

AU - González, Felipe

AU - Ceballos, Guillermo

N1 - Funding Information: MS Abigail Aguilar, IMSS herbarium, for authentication of plant material and Antonio Cervantes. This study was supported by CONACyT (grant: 38030-M); IMSS-FOFOI (FP-2001-053).

PY - 2006/1/3

Y1 - 2006/1/3

N2 - Aqueous and methanolic extracts from 26 medicinal plants used in Mexico to treat gastrointestinal disorders were screened to evaluate their antisecretory activity on cholera toxin-induced intestinal secretion in rat jejunal loops model. Extracts were tested at a dose of 300 mg/kg. From 56 samples tested, both extracts from Chiranthodendron pentadactylon, Hippocratea excelsa and Ocimum basilicum were the most potent with inhibition values ranging from 68.0 to 87.6%. On the other hand, the methanolic extract of Geranium mexicanum (aerial parts) and the aqueous extract of Bocconia frutescens showed the highest activity with inhibition values of 93.4 and 86.0%, respectively. The results obtained in this study give some scientific support to the use of the Mexican medicinal plants employed for the treatment of gastrointestinal disorders such as diarrhea.

AB - Aqueous and methanolic extracts from 26 medicinal plants used in Mexico to treat gastrointestinal disorders were screened to evaluate their antisecretory activity on cholera toxin-induced intestinal secretion in rat jejunal loops model. Extracts were tested at a dose of 300 mg/kg. From 56 samples tested, both extracts from Chiranthodendron pentadactylon, Hippocratea excelsa and Ocimum basilicum were the most potent with inhibition values ranging from 68.0 to 87.6%. On the other hand, the methanolic extract of Geranium mexicanum (aerial parts) and the aqueous extract of Bocconia frutescens showed the highest activity with inhibition values of 93.4 and 86.0%, respectively. The results obtained in this study give some scientific support to the use of the Mexican medicinal plants employed for the treatment of gastrointestinal disorders such as diarrhea.

KW - Antisecretory activity

KW - Aqueous extracts

KW - Cholera toxin

KW - Methanolic extracts

KW - Mexican medicinal plants

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DO - 10.1016/j.jep.2005.06.046

M3 - Artículo

SN - 0378-8741

VL - 103

SP - 66

EP - 70

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

IS - 1

ER -

Antisecretory activity of plants used to treat gastrointestinal disorders in Mexico

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Keywords

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