Antisecretory activity from the flowers of Chiranthodendron pentadactylon and its flavonoids on intestinal fluid accumulation induced by Vibrio cholerae toxin in rats

Claudia Velázquez, Fernando Calzada, Baldomero Esquivel, Elizabeth Barbosa, Samuel Calzada

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Ethnopharmacological relevance: The flowers of Chiranthodendron pentadactylon Larreat. (Sterculiaceae) has been traditionally used as folk medicine in Mexico for the treatment of gastrointestinal disorders such as diarrhea and dysentery. Aim of the study: This study aimed to assess the antisecretory activity which supports the therapeutic use of Chiranthodendron pentadactylon and its flavonoids to treat diarrhea. Materials and methods: The methanol extract of Chiranthodendron pentadactylon, subsequent fractions, and flavonoids were evaluated on cholera toxin-induced intestinal secretion in rat jejunal loops model. Results: Three antisecretory flavonoids were isolated by bioassay-guided purification, namely, isoquercitrin 3, (+)-catechin 4 and (-)-epicatechin 5. Among them, epicatechin exhibited the most potent antisecretory activity with ID50 of 8.3 μM/kg. Its potency was close that of to loperamide (ID50 6.1 μM/kg), drug used as control. Isoquercitrin (ID50 19.2 μM/kg) and catechin (ID50 51.7 μM/kg) showed moderate and weak activity, respectively. Conclusion: The results of the present study lend some support to the anecdotal report for the traditional use of the flowers of Chiranthodendron pentadactylon in the control of dysentery. © 2009 Elsevier Ireland Ltd. All rights reserved.
Original languageAmerican English
Pages (from-to)455-458
Number of pages409
JournalJournal of Ethnopharmacology
DOIs
StatePublished - 10 Dec 2009
Externally publishedYes

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dysentery
Flavonoids
cholera
Vibrio cholerae
Catechin
Cholera Toxin
toxin
Rats
flower
Dysentery
Fluids
fluid
secretion
medicine
purification
methanol
bioassay
Diarrhea
drug
Sterculiaceae

Cite this

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title = "Antisecretory activity from the flowers of Chiranthodendron pentadactylon and its flavonoids on intestinal fluid accumulation induced by Vibrio cholerae toxin in rats",
abstract = "Ethnopharmacological relevance: The flowers of Chiranthodendron pentadactylon Larreat. (Sterculiaceae) has been traditionally used as folk medicine in Mexico for the treatment of gastrointestinal disorders such as diarrhea and dysentery. Aim of the study: This study aimed to assess the antisecretory activity which supports the therapeutic use of Chiranthodendron pentadactylon and its flavonoids to treat diarrhea. Materials and methods: The methanol extract of Chiranthodendron pentadactylon, subsequent fractions, and flavonoids were evaluated on cholera toxin-induced intestinal secretion in rat jejunal loops model. Results: Three antisecretory flavonoids were isolated by bioassay-guided purification, namely, isoquercitrin 3, (+)-catechin 4 and (-)-epicatechin 5. Among them, epicatechin exhibited the most potent antisecretory activity with ID50 of 8.3 μM/kg. Its potency was close that of to loperamide (ID50 6.1 μM/kg), drug used as control. Isoquercitrin (ID50 19.2 μM/kg) and catechin (ID50 51.7 μM/kg) showed moderate and weak activity, respectively. Conclusion: The results of the present study lend some support to the anecdotal report for the traditional use of the flowers of Chiranthodendron pentadactylon in the control of dysentery. {\circledC} 2009 Elsevier Ireland Ltd. All rights reserved.",
author = "Claudia Vel{\'a}zquez and Fernando Calzada and Baldomero Esquivel and Elizabeth Barbosa and Samuel Calzada",
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Antisecretory activity from the flowers of Chiranthodendron pentadactylon and its flavonoids on intestinal fluid accumulation induced by Vibrio cholerae toxin in rats. / Velázquez, Claudia; Calzada, Fernando; Esquivel, Baldomero; Barbosa, Elizabeth; Calzada, Samuel.

In: Journal of Ethnopharmacology, 10.12.2009, p. 455-458.

Research output: Contribution to journalArticle

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T1 - Antisecretory activity from the flowers of Chiranthodendron pentadactylon and its flavonoids on intestinal fluid accumulation induced by Vibrio cholerae toxin in rats

AU - Velázquez, Claudia

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AU - Esquivel, Baldomero

AU - Barbosa, Elizabeth

AU - Calzada, Samuel

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