TY - JOUR
T1 - Antimycobacterial triterpenoids from Lantana hispida (Verbenaceae)
AU - Jiménez-Arellanes, Adelina
AU - Meckes, Mariana
AU - Torres, Javier
AU - Luna-Herrera, Julieta
N1 - Funding Information:
This work was supported by grant FP-0038/717 from the Coordinación Nacional de Investigación en Salud, IMSS, Mexico and grant 30702-N from Consejo Nacional de Ciencia y Tecnología (CONACyT), Mexico. The authors wish to thanks M Sc. Abigail Aguilar from Herbarium IMSSM, for botanical identification of Lantana hispida.
PY - 2007/5/4
Y1 - 2007/5/4
N2 - As the Mycobacterium tuberculosis strains resistant to multiple drugs are increasing at an alarming rate, there is an urgent need for alternative anti-tuberculosis drugs. In a bioassay-guided search for antimycobacterial compounds obtained from higher plants, the study of the hexane extract from the aerial parts of Lantana hispida was performed and the biological activity of the plant products were tested against Mycobacterium tuberculosis H37Rv strain by microdilution alamar blue assay. Activity of the primary fractions led to the isolation of three pentacyclic triterpenoids with oleanane nucleous, together with β-sitosterol. The molecular structures of the compounds were characterized as 3-acetoxy-22-(2′-methyl-2Z-butenyloxy)-12-oleanen-28-oic acid (1), 3-hydroxy-22β-(2′-methyl-2Z-butenoyloxy)-12-oleanen-28-oic acid (reduced lantadene A) (2) and oleanolic acid (3). MIC values for compounds 1 and 2 were 50 μg/ml, and for compound 3 the MIC = 25 μg/ml.
AB - As the Mycobacterium tuberculosis strains resistant to multiple drugs are increasing at an alarming rate, there is an urgent need for alternative anti-tuberculosis drugs. In a bioassay-guided search for antimycobacterial compounds obtained from higher plants, the study of the hexane extract from the aerial parts of Lantana hispida was performed and the biological activity of the plant products were tested against Mycobacterium tuberculosis H37Rv strain by microdilution alamar blue assay. Activity of the primary fractions led to the isolation of three pentacyclic triterpenoids with oleanane nucleous, together with β-sitosterol. The molecular structures of the compounds were characterized as 3-acetoxy-22-(2′-methyl-2Z-butenyloxy)-12-oleanen-28-oic acid (1), 3-hydroxy-22β-(2′-methyl-2Z-butenoyloxy)-12-oleanen-28-oic acid (reduced lantadene A) (2) and oleanolic acid (3). MIC values for compounds 1 and 2 were 50 μg/ml, and for compound 3 the MIC = 25 μg/ml.
KW - Antimycobacterial compounds
KW - Lantana hispida
KW - Mycobacterium tuberculosis
KW - Triterpenoids
UR - http://www.scopus.com/inward/record.url?scp=34047142284&partnerID=8YFLogxK
U2 - 10.1016/j.jep.2006.11.033
DO - 10.1016/j.jep.2006.11.033
M3 - Artículo
SN - 0378-8741
VL - 111
SP - 202
EP - 205
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 2
ER -