Antimicrobial (viral, bacterial, fungal, and parasitic) mechanisms of action of boron-containing compounds

Eunice D. Farfán-García; Ahmet Kilic; Jazmín García-Machorro; M. Emilio Cuevas-Galindo; Brenda A. Rubio-Velazquez; Itzel H. García-Coronel; Elizabeth Estevez-Fregoso; Jose G. Trujillo-Ferrara; Marvin A. Soriano-Ursúa

doi:10.1016/B978-0-323-85730-7.00026-6

Antimicrobial (viral, bacterial, fungal, and parasitic) mechanisms of action of boron-containing compounds

Eunice D. Farfán-García, Ahmet Kilic, Jazmín García-Machorro, M. Emilio Cuevas-Galindo, Brenda A. Rubio-Velazquez, Itzel H. García-Coronel, Elizabeth Estevez-Fregoso, Jose G. Trujillo-Ferrara, Marvin A. Soriano-Ursúa

Escuela Superior de Medicina (ESM)

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Scopus citations

Abstract

Exploration of boron-containing compounds (BBC) has allowed us to introduce them into the antimicrobial toolbox. Natural and synthetic BCC have shown antimicrobial activity in vitro and in vivo. Also, crystal structures and in silico assays have been described to support the safe use to treat infectious diseases in humans. As examples, boric acid, Tavaborole, and Vaborbactam are now available in a human application. In this chapter, we describe the introduction of BCC as antimicrobial agents. This includes the advances in the understanding of their mechanisms of action for limiting viral, bacterial, fungal, and parasitic infections; mainly from the analysis of obtained crystal structures of targeted proteins. In addition, the scope of drug-designing strategies, as well as their chemico-biological properties are found, suggesting advantages in the boron-free compounds, taking into account potential action on drug-resistance microorganisms.

Original language	English
Title of host publication	Viral, Parasitic, Bacterial, and Fungal Infections
Subtitle of host publication	Antimicrobial, Host Defense, and Therapeutic Strategies
Publisher	Elsevier
Pages	733-754
Number of pages	22
ISBN (Electronic)	9780323857307
ISBN (Print)	9780323898003
DOIs	https://doi.org/10.1016/B978-0-323-85730-7.00026-6
State	Published - 1 Jan 2022

Keywords

Antibacterial
Antifungal
Antiparasitic
Antiviral
Boron
Mechanisms of action
Molecular interactions

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-323-85730-7.00026-6

Cite this

Farfán-García, E. D., Kilic, A., García-Machorro, J., Cuevas-Galindo, M. E., Rubio-Velazquez, B. A., García-Coronel, I. H., Estevez-Fregoso, E., Trujillo-Ferrara, J. G., & Soriano-Ursúa, M. A. (2022). Antimicrobial (viral, bacterial, fungal, and parasitic) mechanisms of action of boron-containing compounds. In Viral, Parasitic, Bacterial, and Fungal Infections: Antimicrobial, Host Defense, and Therapeutic Strategies (pp. 733-754). Elsevier. https://doi.org/10.1016/B978-0-323-85730-7.00026-6

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abstract = "Exploration of boron-containing compounds (BBC) has allowed us to introduce them into the antimicrobial toolbox. Natural and synthetic BCC have shown antimicrobial activity in vitro and in vivo. Also, crystal structures and in silico assays have been described to support the safe use to treat infectious diseases in humans. As examples, boric acid, Tavaborole, and Vaborbactam are now available in a human application. In this chapter, we describe the introduction of BCC as antimicrobial agents. This includes the advances in the understanding of their mechanisms of action for limiting viral, bacterial, fungal, and parasitic infections; mainly from the analysis of obtained crystal structures of targeted proteins. In addition, the scope of drug-designing strategies, as well as their chemico-biological properties are found, suggesting advantages in the boron-free compounds, taking into account potential action on drug-resistance microorganisms.",

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Farfán-García, ED, Kilic, A, García-Machorro, J, Cuevas-Galindo, ME, Rubio-Velazquez, BA, García-Coronel, IH, Estevez-Fregoso, E, Trujillo-Ferrara, JG & Soriano-Ursúa, MA 2022, Antimicrobial (viral, bacterial, fungal, and parasitic) mechanisms of action of boron-containing compounds. in Viral, Parasitic, Bacterial, and Fungal Infections: Antimicrobial, Host Defense, and Therapeutic Strategies. Elsevier, pp. 733-754. https://doi.org/10.1016/B978-0-323-85730-7.00026-6

Antimicrobial (viral, bacterial, fungal, and parasitic) mechanisms of action of boron-containing compounds. / Farfán-García, Eunice D.; Kilic, Ahmet; García-Machorro, Jazmín et al.
Viral, Parasitic, Bacterial, and Fungal Infections: Antimicrobial, Host Defense, and Therapeutic Strategies. Elsevier, 2022. p. 733-754.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Antimicrobial (viral, bacterial, fungal, and parasitic) mechanisms of action of boron-containing compounds

AU - Farfán-García, Eunice D.

AU - Kilic, Ahmet

AU - García-Machorro, Jazmín

AU - Cuevas-Galindo, M. Emilio

AU - Rubio-Velazquez, Brenda A.

AU - García-Coronel, Itzel H.

AU - Estevez-Fregoso, Elizabeth

AU - Trujillo-Ferrara, Jose G.

AU - Soriano-Ursúa, Marvin A.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Exploration of boron-containing compounds (BBC) has allowed us to introduce them into the antimicrobial toolbox. Natural and synthetic BCC have shown antimicrobial activity in vitro and in vivo. Also, crystal structures and in silico assays have been described to support the safe use to treat infectious diseases in humans. As examples, boric acid, Tavaborole, and Vaborbactam are now available in a human application. In this chapter, we describe the introduction of BCC as antimicrobial agents. This includes the advances in the understanding of their mechanisms of action for limiting viral, bacterial, fungal, and parasitic infections; mainly from the analysis of obtained crystal structures of targeted proteins. In addition, the scope of drug-designing strategies, as well as their chemico-biological properties are found, suggesting advantages in the boron-free compounds, taking into account potential action on drug-resistance microorganisms.

AB - Exploration of boron-containing compounds (BBC) has allowed us to introduce them into the antimicrobial toolbox. Natural and synthetic BCC have shown antimicrobial activity in vitro and in vivo. Also, crystal structures and in silico assays have been described to support the safe use to treat infectious diseases in humans. As examples, boric acid, Tavaborole, and Vaborbactam are now available in a human application. In this chapter, we describe the introduction of BCC as antimicrobial agents. This includes the advances in the understanding of their mechanisms of action for limiting viral, bacterial, fungal, and parasitic infections; mainly from the analysis of obtained crystal structures of targeted proteins. In addition, the scope of drug-designing strategies, as well as their chemico-biological properties are found, suggesting advantages in the boron-free compounds, taking into account potential action on drug-resistance microorganisms.

KW - Antibacterial

KW - Antifungal

KW - Antiparasitic

KW - Antiviral

KW - Boron

KW - Mechanisms of action

KW - Molecular interactions

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U2 - 10.1016/B978-0-323-85730-7.00026-6

DO - 10.1016/B978-0-323-85730-7.00026-6

M3 - Capítulo

AN - SCOPUS:85148708933

SN - 9780323898003

SP - 733

EP - 754

BT - Viral, Parasitic, Bacterial, and Fungal Infections

PB - Elsevier

ER -

Farfán-García ED, Kilic A, García-Machorro J, Cuevas-Galindo ME, Rubio-Velazquez BA, García-Coronel IH et al. Antimicrobial (viral, bacterial, fungal, and parasitic) mechanisms of action of boron-containing compounds. In Viral, Parasitic, Bacterial, and Fungal Infections: Antimicrobial, Host Defense, and Therapeutic Strategies. Elsevier. 2022. p. 733-754 doi: 10.1016/B978-0-323-85730-7.00026-6

Antimicrobial (viral, bacterial, fungal, and parasitic) mechanisms of action of boron-containing compounds

Abstract

Keywords

UN SDGs

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