Antimicrobial activity induced by a sulfathiazole derivative on Staphylococcus aureus, and Vibrio cholerae

In this work the antibacterial activity of asulfathiazole derivative was evaluated against both Staphylococcus aureus and Vibrio cholerae using cefotaxime, gentamicin, ciprofloxacin and sulfathiazole as controls. The evaluation of antimicrobial effect of the different compounds on the bacterial species was made by the method of microbial minimal inhibitory. The results indicate that bacterial growth of Staphylococcus aureusand Vibrio choleraewas inhibited with cefotaxime(MIC=5. 23 × 10^-4 mmol), gentamicin(MIC=2. 68 × 10^-5 mmol), ciprofloxacin (MIC=3. 77 × 10^-4 mmol) andsulphathiazole derivative(MIC= 4. 10× 10^-3 mmol). To delineate the structural chemical requirements of sulfathiazole derivative as antibacterial agent againstStaphylococcus aureusand Vibrio cholerae, otherparameters such as the descriptors logP andπ were calculated. The results showed anincrease in the values of logP andπ for the sulfathiazole derivative in comparison with sulfathiazole. These data suggest a relationship between the physicochemical parameters evaluated and the degree of lipophilicityof the sulfathiazole derivative. Therefore, possibly the antibacterial activity of thesulfathiazole derivativecould depend of lipophilicity degree of sulfathiazole derivative in comparison with sulphathiazole.