TY - JOUR
T1 - Antidepressant-like effects of dracocephalum moldavica l. In mouse models of immobility tests
AU - Zúñiga, Marcos Ignacio Jiménez
AU - Mariles, Alejandro Jonathan Hurtado
AU - Flores, José Luis Castrejón
AU - Herrera, José Antonio Mondragón
AU - Sotelo, María Guadalupe Ramírez
AU - Montes, Genaro Iván Cerón
AU - De Las Mercedes Gómez Y Gómez, Yolanda
N1 - Publisher Copyright:
© 2019 Phcogj.Com.
PY - 2019
Y1 - 2019
N2 - The aim of this investigation was to evaluate the antidepressant activity of the ethanolic extracts of "toronjil azul"(Dracocephalum moldavica L.). Methodology: The forced swimming test (FST) and tail suspension test (TST) were performed on CD-1 mice to evaluate the antidepressant activity of the ethanolic extracts. The ethanolic extracts were administered orally at an 80 and 100 mg/kg. The animals were dosed 1, 6 and 24 h before initiating the FST assay and 40 minutes before for the TST assay. Imipramine and fluoxetine were dosed at 15 mg/kg, while the flavonoid quercetin was given an a lower concentration of 10 mg/kg as a positive controls. Results: The extracts of Dracocephalum moldavica L. and significantly decreased the immobility time in the FST and TST assays when compared with the negative control and reported similar values than those obtained with the positive controls. Conclusion: The results obtained indicate that extract of Dracocephalum moldavica L. have antidepressant effect similar to those obtained by.
AB - The aim of this investigation was to evaluate the antidepressant activity of the ethanolic extracts of "toronjil azul"(Dracocephalum moldavica L.). Methodology: The forced swimming test (FST) and tail suspension test (TST) were performed on CD-1 mice to evaluate the antidepressant activity of the ethanolic extracts. The ethanolic extracts were administered orally at an 80 and 100 mg/kg. The animals were dosed 1, 6 and 24 h before initiating the FST assay and 40 minutes before for the TST assay. Imipramine and fluoxetine were dosed at 15 mg/kg, while the flavonoid quercetin was given an a lower concentration of 10 mg/kg as a positive controls. Results: The extracts of Dracocephalum moldavica L. and significantly decreased the immobility time in the FST and TST assays when compared with the negative control and reported similar values than those obtained with the positive controls. Conclusion: The results obtained indicate that extract of Dracocephalum moldavica L. have antidepressant effect similar to those obtained by.
KW - Depression
KW - Dracochepalum moldavica L.
KW - Forced swim test
KW - Tail suspension test
UR - http://www.scopus.com/inward/record.url?scp=85072596298&partnerID=8YFLogxK
U2 - 10.5530/pj.2019.11.154
DO - 10.5530/pj.2019.11.154
M3 - Artículo
SN - 0975-3575
VL - 11
SP - 976
EP - 983
JO - Pharmacognosy Journal
JF - Pharmacognosy Journal
IS - 5
ER -