TY - JOUR
T1 - Antidepressant-like and toxicological effects of a standardized aqueous extract of Chrysactinia mexicana A. Gray (Asteraceae) in mice
AU - Cassani, Julia
AU - Alberto Ferreyra-Cruz, Octavio
AU - María Dorantes-Barrón, Ana
AU - Vigueras Villaseñor, Rosa María
AU - Arrieta-Baez, Daniel
AU - Estrada-Reyes, Rosa
N1 - Publisher Copyright:
© 2015 Elsevier Ireland Ltd. All rights reserved.
PY - 2015/6/26
Y1 - 2015/6/26
N2 - Ethnopharmacological relevance C. mexicana A. Gray (Asteraceae) is a native of North America plant. In Mexico's folk medicine it is used for the fever, rheumatism and as a diuretic, antispasmodic, general tonic or adaptogenic herb, and as a stimulant agent. The aim of the study was to examine the antidepressant-like properties of an aqueous extract of C. mexicana (Cm), in order to scientifically describe its potential value in the management of depressive disorders. To evaluate the acute and subacute toxic effects of Cm and effects on hepatic and biochemical functions in mice. Materials and methods Antidepressant-like effects of Cm were evaluated in the Forced swimming and suspension tail tests (FST and TST), the ambulatory activity was measure in the Open Field Test (OFT), motor coordination was evaluated in the inverted screen and gyratory roller (IST and Rota-rod), the biochemical and histopathological analysis were carried out. Phytochemical studies of organic and aqueous extracts of Cm were thoroughly conducted. Results Cm produced a significant reduction of the immobility time both FST and in TST, without affect the ambulatory activity of experimental mice. Cm did not produce any damage in the hepatic functions, nor produce any significant change in the morphological tissue of organs examined. Conclusions Chrysactinia mexicana induces a clear antidepressant-like effect in mice, without affect any basic functions. The consumption of this medicinal plant does not represent risk for health. The chemical analysis showed the flavonoids free and glycosides mainly.
AB - Ethnopharmacological relevance C. mexicana A. Gray (Asteraceae) is a native of North America plant. In Mexico's folk medicine it is used for the fever, rheumatism and as a diuretic, antispasmodic, general tonic or adaptogenic herb, and as a stimulant agent. The aim of the study was to examine the antidepressant-like properties of an aqueous extract of C. mexicana (Cm), in order to scientifically describe its potential value in the management of depressive disorders. To evaluate the acute and subacute toxic effects of Cm and effects on hepatic and biochemical functions in mice. Materials and methods Antidepressant-like effects of Cm were evaluated in the Forced swimming and suspension tail tests (FST and TST), the ambulatory activity was measure in the Open Field Test (OFT), motor coordination was evaluated in the inverted screen and gyratory roller (IST and Rota-rod), the biochemical and histopathological analysis were carried out. Phytochemical studies of organic and aqueous extracts of Cm were thoroughly conducted. Results Cm produced a significant reduction of the immobility time both FST and in TST, without affect the ambulatory activity of experimental mice. Cm did not produce any damage in the hepatic functions, nor produce any significant change in the morphological tissue of organs examined. Conclusions Chrysactinia mexicana induces a clear antidepressant-like effect in mice, without affect any basic functions. The consumption of this medicinal plant does not represent risk for health. The chemical analysis showed the flavonoids free and glycosides mainly.
KW - Chrysactinia Mexicana
KW - Damiana false
KW - Damianita
KW - Depression
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=84933544022&partnerID=8YFLogxK
U2 - 10.1016/j.jep.2015.05.055
DO - 10.1016/j.jep.2015.05.055
M3 - Artículo
C2 - 26070520
SN - 0378-8741
VL - 171
SP - 295
EP - 306
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
ER -