TY - JOUR
T1 - Anticancer activity and anti-inflammatory studies of 5-Aryl-1,4-benzodiazepine derivatives
AU - Sandra, Cortez Maya
AU - Eduardo, Cortés Cortés
AU - Simón, Hernández Ortega
AU - Teresa, Ramírez Apan
AU - Antonio, Nieto Camacho
AU - Lijanova, Irina V.
AU - Marcos, Martínez García
PY - 2012/7
Y1 - 2012/7
N2 - A series of 5-aryl-1,4-benzodiazepines with chloro- or fluoro-substituents in the second ring have been synthesized and their anti-inflammatory, myeloperoxidase and anticancer properties studied. The synthesized compounds showed potential anti-inflammatory and anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4-benzodiazepine.
AB - A series of 5-aryl-1,4-benzodiazepines with chloro- or fluoro-substituents in the second ring have been synthesized and their anti-inflammatory, myeloperoxidase and anticancer properties studied. The synthesized compounds showed potential anti-inflammatory and anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4-benzodiazepine.
KW - 1,4-benzodiazepines
KW - Anti-inflammatory
KW - Anticancer activity
KW - Myeloperoxidase
UR - http://www.scopus.com/inward/record.url?scp=84861684835&partnerID=8YFLogxK
U2 - 10.2174/187152012800617713
DO - 10.2174/187152012800617713
M3 - Artículo
SN - 1871-5206
VL - 12
SP - 611
EP - 618
JO - Anti-Cancer Agents in Medicinal Chemistry
JF - Anti-Cancer Agents in Medicinal Chemistry
IS - 6
ER -