TY - JOUR
T1 - Anti-Inflammatory and Neuroprotective Effects of Standardized Fractions in Herniarin and Daphnoretin from Distictis buccinatoria
AU - Liliana Porras-Dávila, Sandra
AU - Zamilpa, Alejandro
AU - Jiménez-Ferrer, Enrique
AU - Jiménez-Aparicio, Antonio
AU - Alejandra Santillan-Urquiza, Mayra
AU - Díaz-Patricio, Fernanda
AU - Herrera-Ruiz, Maribel
N1 - Publisher Copyright:
© 2023 Wiley-VHCA AG, Zurich, Switzerland.
PY - 2023/5
Y1 - 2023/5
N2 - Distictis buccinatoria is used for inflammatory-related diseases. From a dichloromethane extract were obtained five different fractions called F1 to F5, and sub-fractions F4-1, F5-1, F5-2, and F5-3; and were evaluated as anti-neuroinflammatory, antioxidant, and nootropic agents in mice exposed to lipopolysaccharide. Also, were isolated herniarin, daphnoretin, and fraction's terpenes with an anti-inflammatory activity using 12-O-tetradecanoylphorbol-13-acetate-induced auricular edema. The inhibition of local edema was: F1 (73.6 %), F2 (57 %), F3 (62.61 %), F4 (87.3 %), and F5 (93.57 %). Terpene fraction inhibited at 89.60 %, herniarin at 86.92 % (Emax 99.01 %, ED50 0.35 mg ear−1), and daphnoretin at 86.41 %. Fractions F4-1 and F5-2 (10 mg kg−1) enhancer spatial memory acquisition and spontaneous motor activity; reduced IL-1β, TNF-α, and IL-6; increased IL-10, enhanced the activity of CAT and GR. D. buccinatoria has neuroprotective activity and contains daphnoretin and herniarin, with anti-inflammatory activity.
AB - Distictis buccinatoria is used for inflammatory-related diseases. From a dichloromethane extract were obtained five different fractions called F1 to F5, and sub-fractions F4-1, F5-1, F5-2, and F5-3; and were evaluated as anti-neuroinflammatory, antioxidant, and nootropic agents in mice exposed to lipopolysaccharide. Also, were isolated herniarin, daphnoretin, and fraction's terpenes with an anti-inflammatory activity using 12-O-tetradecanoylphorbol-13-acetate-induced auricular edema. The inhibition of local edema was: F1 (73.6 %), F2 (57 %), F3 (62.61 %), F4 (87.3 %), and F5 (93.57 %). Terpene fraction inhibited at 89.60 %, herniarin at 86.92 % (Emax 99.01 %, ED50 0.35 mg ear−1), and daphnoretin at 86.41 %. Fractions F4-1 and F5-2 (10 mg kg−1) enhancer spatial memory acquisition and spontaneous motor activity; reduced IL-1β, TNF-α, and IL-6; increased IL-10, enhanced the activity of CAT and GR. D. buccinatoria has neuroprotective activity and contains daphnoretin and herniarin, with anti-inflammatory activity.
KW - Distictis buccinatoria
KW - LPS
KW - antioxidant enzymes
KW - coumarins
KW - memory
UR - http://www.scopus.com/inward/record.url?scp=85159878982&partnerID=8YFLogxK
U2 - 10.1002/cbdv.202200969
DO - 10.1002/cbdv.202200969
M3 - Artículo
C2 - 36973180
AN - SCOPUS:85159878982
SN - 1612-1872
VL - 20
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 5
M1 - e202200969
ER -