TY - JOUR
T1 - Anti-inflammatory activity of cacalol and cacalone sesquiterpenes isolated from Psacalium decompositum
AU - Jimenez-Estrada, M.
AU - Chilpa, R. Reyes
AU - Apan, T. Ramirez
AU - Lledias, Fernando
AU - Hansberg, Wilhem
AU - Arrieta, Daniel
AU - Aguilar, F. J.Alarcon
N1 - Funding Information:
This work was supported in part by grant IN206999 from DGAPA, National University of México City.
PY - 2006/4/21
Y1 - 2006/4/21
N2 - The hexane extract and two sesquiterpenic compounds, cacalol and cacalone, were isolated from the roots and rhizomes of Psacalium decompositum. Then, their anti-inflammatory activity was evaluated in carrageenan-induced rat paw edema and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema. Indomethacin was used as the anti-inflammatory agent of reference. In the rat paw model of inflammation, both the hexane extract and the sesquiterpenes isolated from Psacalium decompositum showed a clear dose-dependent inhibition of the carrageenan-induced edema (P < 0.05), with important differences among them during the temporal course of the inhibition. In the TPA-induced mouse ear edema all tested compounds showed anti-inflammatory activity in dose-dependent manner (P < 0.05). In both models, cacalone showed the most prominent anti-inflammatory activity. We conclude that some of the beneficial effects attributed to Psacalium decompositum in traditional medicine can be related with the anti-inflammatory activity of cacalol and cacalone.
AB - The hexane extract and two sesquiterpenic compounds, cacalol and cacalone, were isolated from the roots and rhizomes of Psacalium decompositum. Then, their anti-inflammatory activity was evaluated in carrageenan-induced rat paw edema and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema. Indomethacin was used as the anti-inflammatory agent of reference. In the rat paw model of inflammation, both the hexane extract and the sesquiterpenes isolated from Psacalium decompositum showed a clear dose-dependent inhibition of the carrageenan-induced edema (P < 0.05), with important differences among them during the temporal course of the inhibition. In the TPA-induced mouse ear edema all tested compounds showed anti-inflammatory activity in dose-dependent manner (P < 0.05). In both models, cacalone showed the most prominent anti-inflammatory activity. We conclude that some of the beneficial effects attributed to Psacalium decompositum in traditional medicine can be related with the anti-inflammatory activity of cacalol and cacalone.
KW - Anti-inflammatory activity
KW - Cacalia decomposita
KW - Cacalol
KW - Cacalone
KW - Psacalium decompositum
KW - Sesquiterpenic compounds
UR - http://www.scopus.com/inward/record.url?scp=33645312350&partnerID=8YFLogxK
U2 - 10.1016/j.jep.2005.09.039
DO - 10.1016/j.jep.2005.09.039
M3 - Artículo
SN - 0378-8741
VL - 105
SP - 34
EP - 38
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 1-2
ER -