TY - JOUR
T1 - Angiotensin-II type 1 receptor (AT1R) and alpha-1D adrenoceptor form a heterodimer during pregnancy-induced hypertension
AU - González-Hernández, M. De Lourdes
AU - Godínez-Hernández, D.
AU - Bobadilla-Lugo, R. A.
AU - López-Sánchez, P.
PY - 2010/7
Y1 - 2010/7
N2 - 1 Pregnancy courses with low response to angiotensin II and adrenergic agonists. In preeclampsia, both effects are reverted. It is known that angiotensin II regulates adrenergic system. It is not known, however, the interaction between both systems receptors. 2 Our aim was to study if AT 1R and α1D adrenoceptor heterodimerize in preeclampsia. 3 We used subrenal aorctic coarctation in pregnant rats. Aortic tissues were prepared for confocal imaging and coimmunoprecipitated for α1D and AT1 receptors. 4 We found that AT1R and α1D adrenoceptor heterodimerize in both, healthy and preeclamptic groups. In healthy pregnant rats, heterodimer is barely detected. In preeclamptic rats however, we found higher heterodimerization. 5 These results suggest that AT1R and α1D-adrenoceptor may form heterodimers, and may play a role in preeclampsia.
AB - 1 Pregnancy courses with low response to angiotensin II and adrenergic agonists. In preeclampsia, both effects are reverted. It is known that angiotensin II regulates adrenergic system. It is not known, however, the interaction between both systems receptors. 2 Our aim was to study if AT 1R and α1D adrenoceptor heterodimerize in preeclampsia. 3 We used subrenal aorctic coarctation in pregnant rats. Aortic tissues were prepared for confocal imaging and coimmunoprecipitated for α1D and AT1 receptors. 4 We found that AT1R and α1D adrenoceptor heterodimerize in both, healthy and preeclamptic groups. In healthy pregnant rats, heterodimer is barely detected. In preeclamptic rats however, we found higher heterodimerization. 5 These results suggest that AT1R and α1D-adrenoceptor may form heterodimers, and may play a role in preeclampsia.
KW - AT receptor
KW - Animal models
KW - Hypertension
KW - Preeclampsia
KW - Pregnancy
KW - α1 receptor
UR - http://www.scopus.com/inward/record.url?scp=77953525974&partnerID=8YFLogxK
U2 - 10.1111/j.1474-8673.2009.00446.x
DO - 10.1111/j.1474-8673.2009.00446.x
M3 - Artículo
C2 - 20102360
SN - 1474-8665
VL - 30
SP - 167
EP - 172
JO - Autonomic and Autacoid Pharmacology
JF - Autonomic and Autacoid Pharmacology
IS - 3
ER -