TY - JOUR
T1 - Angiotensin Converting Enzyme 1 Polymorphisms and Lipid Profile in Mexican Patients With COVID-19
AU - Mateos, Evelyn Romero
AU - Zarate, Paola Berenice
AU - Gonzalez, Fernando Bastida
AU - Perez-Mendez, Maria Jose
AU - Dávila-Gonzalez, Eduardo
AU - Garduno-Gutierrez, Aaron
AU - Sotelo-Salas, Rosalva
AU - Juan, Ceballos Macias Jose
AU - Horacio, Sosa Corales
AU - Francisco, Lucio Monter Pascual
AU - Villanueva, Cleva
N1 - Publisher Copyright:
© 2023 International Institute of Anticancer Research. All rights reserved.
PY - 2023/1
Y1 - 2023/1
N2 - Background/Aim: Renin-angiotensin system (RAS) is present in a diverse type of cells and plays an important role in lung physiology and pathophysiology. Angiotensin converting enzymes (ACE) are part of the RAS system. There are still controversies about the association of I/D polymorphisms of ACE1 with COVID-19 severity. The goal of the study was to determine whether there is an association of the I/D polymorphism with severity of COVID-19 in Mexican patients. Patients and Methods: The study included voluntary participants: 53 healthy individuals negative to RT-PCR COVID-19 (control), and 165 patients positive to COVID-19. Severity was defined by the need of hospitalization, invasive ventilation, shock, or multiple organ failure. The patient group consisted of 28 asymptomatic, 82 with mild, and 55 with severe COVID-19. I/D polymorphism was determined by PCR. Rutinary laboratory tests were performed in all the participants. Results: DD polymorphism was significantly associated with severe COVID-19, independently of comorbidities, or any other variable. Receiver operator characteristic curves demonstrated association of low total cholesterol, low high-density lipoproteins, and high c-reactive protein with severity of COVID-19. Conclusion: The DD polymorphism was associated with the course of the infection and severity of COVID-19 in a sample of Mexican patients.
AB - Background/Aim: Renin-angiotensin system (RAS) is present in a diverse type of cells and plays an important role in lung physiology and pathophysiology. Angiotensin converting enzymes (ACE) are part of the RAS system. There are still controversies about the association of I/D polymorphisms of ACE1 with COVID-19 severity. The goal of the study was to determine whether there is an association of the I/D polymorphism with severity of COVID-19 in Mexican patients. Patients and Methods: The study included voluntary participants: 53 healthy individuals negative to RT-PCR COVID-19 (control), and 165 patients positive to COVID-19. Severity was defined by the need of hospitalization, invasive ventilation, shock, or multiple organ failure. The patient group consisted of 28 asymptomatic, 82 with mild, and 55 with severe COVID-19. I/D polymorphism was determined by PCR. Rutinary laboratory tests were performed in all the participants. Results: DD polymorphism was significantly associated with severe COVID-19, independently of comorbidities, or any other variable. Receiver operator characteristic curves demonstrated association of low total cholesterol, low high-density lipoproteins, and high c-reactive protein with severity of COVID-19. Conclusion: The DD polymorphism was associated with the course of the infection and severity of COVID-19 in a sample of Mexican patients.
KW - ACE-1
KW - COVID-19
KW - I/D polymorphism
KW - asymptomatic
KW - lipid profile
KW - severe
UR - http://www.scopus.com/inward/record.url?scp=85145492418&partnerID=8YFLogxK
U2 - 10.21873/invivo.13096
DO - 10.21873/invivo.13096
M3 - Artículo
C2 - 36593047
AN - SCOPUS:85145492418
SN - 0258-851X
VL - 37
SP - 433
EP - 439
JO - In Vivo
JF - In Vivo
IS - 1
ER -