TY - JOUR
T1 - An update of the unceasingly growing and diverse AraC/XylS family of transcriptional activators
AU - Cortés-Avalos, Daniel
AU - Martínez-Pérez, Noemy
AU - Ortiz-Moncada, Mario A.
AU - Juárez-González, Aylin
AU - Baños-Vargas, Arturo A.
AU - Los Santos, Paulina Estrada De
AU - Pérez-Rueda, Ernesto
AU - Antonio Ibarra, J.
N1 - Publisher Copyright:
© 2021 The Author(s). Published by Oxford University Press on behalf of FEMS.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Transcriptional factors play an important role in gene regulation in all organisms, especially in Bacteria. Here special emphasis is placed in the AraC/XylS family of transcriptional regulators. This is one of the most abundant as many predicted members have been identified and more members are added because more bacterial genomes are sequenced. Given the way more experimental evidence has mounded in the past decades, we decided to update the information about this captivating family of proteins. Using bioinformatics tools on all the data available for experimentally characterized members of this family, we found that many members that display a similar functional classification can be clustered together and in some cases they have a similar regulatory scheme. A proposal for grouping these proteins is also discussed. Additionally, an analysis of surveyed proteins in bacterial genomes is presented. Altogether, the current review presents a panoramic view into this family and we hope it helps to stimulate future research in the field.
AB - Transcriptional factors play an important role in gene regulation in all organisms, especially in Bacteria. Here special emphasis is placed in the AraC/XylS family of transcriptional regulators. This is one of the most abundant as many predicted members have been identified and more members are added because more bacterial genomes are sequenced. Given the way more experimental evidence has mounded in the past decades, we decided to update the information about this captivating family of proteins. Using bioinformatics tools on all the data available for experimentally characterized members of this family, we found that many members that display a similar functional classification can be clustered together and in some cases they have a similar regulatory scheme. A proposal for grouping these proteins is also discussed. Additionally, an analysis of surveyed proteins in bacterial genomes is presented. Altogether, the current review presents a panoramic view into this family and we hope it helps to stimulate future research in the field.
KW - AraC/XylS
KW - Biotechnology
KW - Gene regulation
KW - Regulatory networks
KW - Transcriptional factors
UR - http://www.scopus.com/inward/record.url?scp=85114608331&partnerID=8YFLogxK
U2 - 10.1093/femsre/fuab020
DO - 10.1093/femsre/fuab020
M3 - Artículo de revisión
C2 - 33837749
AN - SCOPUS:85114608331
SN - 0168-6445
VL - 45
JO - FEMS Microbiology Reviews
JF - FEMS Microbiology Reviews
IS - 5
M1 - fuab020
ER -