TY - JOUR
T1 - An overview on steroids and microwave energy in multi-component reactions towards the synthesis of novel hybrid molecules
AU - Borah, Preetismita
AU - Shivling, Vhatkar Dattatraya
AU - Banik, Bimal Krishna
AU - Sahoo, Biswa Mohan
N1 - Publisher Copyright:
© 2020 Bentham Science Publishers.
PY - 2020
Y1 - 2020
N2 - In recent years, hybrid systems are gaining considerable attention owing to their various biological applications in drug development. Generally, hybrid molecules are constructed from different molecular entities to generate a new functional molecule with improved biological activities. There already exist a large number of naturally occurring hybrid molecules based on both non-steroid and steroid frameworks synthesized by nature through mixed biosynthetic pathways such as, a) integration of the different biosynthetic pathways or b) CarbonCarbon bond formation between different components derived through different biosynthetic pathways. Multicomponent reactions are a great way to generate efficient libraries of hybrid compounds with high diversity. Throughout the scientific history, the most common factors developing technologies are less energy consumption and avoiding the use of hazardous reagents. In this case, microwave energy plays a vital role in chemical transformations since it involves two very essential criteria of synthesis, minimizing energy consumption required for heating and time required for the reaction. This review summarizes the use of microwave energy in the synthesis of steroidal and non-steroidal hybrid molecules and the use of multicomponent reactions.
AB - In recent years, hybrid systems are gaining considerable attention owing to their various biological applications in drug development. Generally, hybrid molecules are constructed from different molecular entities to generate a new functional molecule with improved biological activities. There already exist a large number of naturally occurring hybrid molecules based on both non-steroid and steroid frameworks synthesized by nature through mixed biosynthetic pathways such as, a) integration of the different biosynthetic pathways or b) CarbonCarbon bond formation between different components derived through different biosynthetic pathways. Multicomponent reactions are a great way to generate efficient libraries of hybrid compounds with high diversity. Throughout the scientific history, the most common factors developing technologies are less energy consumption and avoiding the use of hazardous reagents. In this case, microwave energy plays a vital role in chemical transformations since it involves two very essential criteria of synthesis, minimizing energy consumption required for heating and time required for the reaction. This review summarizes the use of microwave energy in the synthesis of steroidal and non-steroidal hybrid molecules and the use of multicomponent reactions.
KW - Carbon-carbon bond formation
KW - Hazardous reagents
KW - Hybrid molecule
KW - Microwave energy
KW - Steroids
KW - Ugi-4CR
UR - http://www.scopus.com/inward/record.url?scp=85095607775&partnerID=8YFLogxK
U2 - 10.2174/1570179417666200503050106
DO - 10.2174/1570179417666200503050106
M3 - Artículo de revisión
C2 - 32359339
AN - SCOPUS:85095607775
SN - 1570-1794
VL - 17
SP - 594
EP - 609
JO - Current Organic Synthesis
JF - Current Organic Synthesis
IS - 8
ER -