An easy and direct method for the synthesis of 1,2,4-triazole derivatives through carboxylic acids and hydrazinophthalazine

Gildardo Rivera; Virgilio Bocanegra-Garcia; Antonio Moreno; Silvia Galiano; Silvia Pérez; Ignacio Aldana; Antonio Monge

doi:10.1590/S0100-40422008000300014

An easy and direct method for the synthesis of 1,2,4-triazole derivatives through carboxylic acids and hydrazinophthalazine

Gildardo Rivera, Virgilio Bocanegra-Garcia, Antonio Moreno, Silvia Galiano, Silvia Pérez, Ignacio Aldana, Antonio Monge

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We have developed an easy method for the synthesis of thirteen compounds derived from 1,2,4-triazoles through a carboxylic acid and hydrazinophthalazine reaction, with a 75-85% yield mediated by the use of agents such as 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride and 1-hydroxybenzotriazole. The operational simplicity of this method and the good yield of products make it valuable for the synthesis of new compounds with pharmacological activity.

Original language	English
Pages (from-to)	536-538
Number of pages	3
Journal	Quimica Nova
Volume	31
Issue number	3
DOIs	https://doi.org/10.1590/S0100-40422008000300014
State	Published - 2008
Externally published	Yes

Keywords

1,2,4-triazoles
Carboxylic acids
Hydrazinophthalazine

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10.1590/S0100-40422008000300014

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title = "An easy and direct method for the synthesis of 1,2,4-triazole derivatives through carboxylic acids and hydrazinophthalazine",

abstract = "We have developed an easy method for the synthesis of thirteen compounds derived from 1,2,4-triazoles through a carboxylic acid and hydrazinophthalazine reaction, with a 75-85% yield mediated by the use of agents such as 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride and 1-hydroxybenzotriazole. The operational simplicity of this method and the good yield of products make it valuable for the synthesis of new compounds with pharmacological activity.",

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T1 - An easy and direct method for the synthesis of 1,2,4-triazole derivatives through carboxylic acids and hydrazinophthalazine

AU - Rivera, Gildardo

AU - Bocanegra-Garcia, Virgilio

AU - Moreno, Antonio

AU - Galiano, Silvia

AU - Pérez, Silvia

AU - Aldana, Ignacio

AU - Monge, Antonio

PY - 2008

Y1 - 2008

N2 - We have developed an easy method for the synthesis of thirteen compounds derived from 1,2,4-triazoles through a carboxylic acid and hydrazinophthalazine reaction, with a 75-85% yield mediated by the use of agents such as 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride and 1-hydroxybenzotriazole. The operational simplicity of this method and the good yield of products make it valuable for the synthesis of new compounds with pharmacological activity.

AB - We have developed an easy method for the synthesis of thirteen compounds derived from 1,2,4-triazoles through a carboxylic acid and hydrazinophthalazine reaction, with a 75-85% yield mediated by the use of agents such as 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride and 1-hydroxybenzotriazole. The operational simplicity of this method and the good yield of products make it valuable for the synthesis of new compounds with pharmacological activity.

KW - 1,2,4-triazoles

KW - Carboxylic acids

KW - Hydrazinophthalazine

UR - http://www.scopus.com/inward/record.url?scp=45849117553&partnerID=8YFLogxK

U2 - 10.1590/S0100-40422008000300014

DO - 10.1590/S0100-40422008000300014

M3 - Artículo

SN - 0100-4042

VL - 31

SP - 536

EP - 538

JO - Quimica Nova

JF - Quimica Nova

IS - 3

ER -

An easy and direct method for the synthesis of 1,2,4-triazole derivatives through carboxylic acids and hydrazinophthalazine

Abstract

Keywords

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