TY - JOUR
T1 - Aluminum-induced oxidative stress and neurotoxicity in grass carp (Cyprinidae-Ctenopharingodon idella)
AU - Fernández-Dávila, María Lourdes
AU - Razo-Estrada, Amparo Celene
AU - García-Medina, Sandra
AU - Gómez-Oliván, Leobardo Manuel
AU - Piñón-López, Manuel Jesús
AU - Ibarra, Rocio Guzmán
AU - Galar-Martínez, Marcela
N1 - Funding Information:
This study was made possible through support from the Consejo Nacional de Ciencia y Tecnología (CONACyT, Project 57321 ) as well as the Secretaría de Investigación y Posgrado of the Instituto Politécnico Nacional (SIP-IPN, Projects 20060186 and 200704594 ).
PY - 2012/2/1
Y1 - 2012/2/1
N2 - Aluminum is used in a large number of anthropogenic processes, leading to aquatic ecosystems pollution. Diverse studies show that in mammals this metal may produce oxidative stress, is neurotoxic, and is involved in the development of neurodegenerative disorders, such as Alzhaimer's and Parkinson's diseases. Nevertheless, there are only few studies with respect to Al-induced neurotoxicity on aquatic fauna, particularly on fishes of economical interest, such as the grass carp (Ctenopharingodon idella). This study evaluates Al-induced toxicity on the grass carp C. idella. Specimens were exposed to the maximum concentration allowed in order to protect aquatic life (0.1mgL-1), for 12, 24, 48, 72 and 96h. After the exposure time, lipid peroxidation degree, superoxide dismutase and catalase activity, as well as dopamine, adrenaline and noradrenaline levels were evaluated. Al concentration in organisms and water was also measured, in order to determine the bioconcentration factor. Results show that Al bioconcentrates in grass carp inducing oxidative stress (increment of 300 and 455 percent on lipid peroxidation degree and SOD activity, and decrement of 49 percent on CAT activity) and neurotoxicity (increment of 55 and 155 percent on dopamine and adrenaline levels and decrement of 93 percent on noradrenaline level).
AB - Aluminum is used in a large number of anthropogenic processes, leading to aquatic ecosystems pollution. Diverse studies show that in mammals this metal may produce oxidative stress, is neurotoxic, and is involved in the development of neurodegenerative disorders, such as Alzhaimer's and Parkinson's diseases. Nevertheless, there are only few studies with respect to Al-induced neurotoxicity on aquatic fauna, particularly on fishes of economical interest, such as the grass carp (Ctenopharingodon idella). This study evaluates Al-induced toxicity on the grass carp C. idella. Specimens were exposed to the maximum concentration allowed in order to protect aquatic life (0.1mgL-1), for 12, 24, 48, 72 and 96h. After the exposure time, lipid peroxidation degree, superoxide dismutase and catalase activity, as well as dopamine, adrenaline and noradrenaline levels were evaluated. Al concentration in organisms and water was also measured, in order to determine the bioconcentration factor. Results show that Al bioconcentrates in grass carp inducing oxidative stress (increment of 300 and 455 percent on lipid peroxidation degree and SOD activity, and decrement of 49 percent on CAT activity) and neurotoxicity (increment of 55 and 155 percent on dopamine and adrenaline levels and decrement of 93 percent on noradrenaline level).
KW - Aluminum
KW - Bioconcentration
KW - Grass carp
KW - Neurotoxicity
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=82055172754&partnerID=8YFLogxK
U2 - 10.1016/j.ecoenv.2011.09.012
DO - 10.1016/j.ecoenv.2011.09.012
M3 - Artículo
C2 - 21993346
AN - SCOPUS:82055172754
SN - 0147-6513
VL - 76
SP - 87
EP - 92
JO - Ecotoxicology and Environmental Safety
JF - Ecotoxicology and Environmental Safety
IS - 1
ER -