Altered β-amyloid precursor protein isoforms in Mexican Alzheimer's Disease patients

V. J. Sánchez-González; G. G. Ortiz; P. Gallegos-Arreola; M. A. Macías-Islas; E. D. Arias-Merino; V. Loera-Castañeda; E. Martínez-Cano; I. E. Velázquez-Brizuela; S. A. Rosales-Corral; C. R. Curiel-Ortega; F. Pacheco-Moisés; J. J. García

doi:10.1155/2006/347502

Altered β-amyloid precursor protein isoforms in Mexican Alzheimer's Disease patients

V. J. Sánchez-González, G. G. Ortiz, P. Gallegos-Arreola, M. A. Macías-Islas, E. D. Arias-Merino, V. Loera-Castañeda, E. Martínez-Cano, I. E. Velázquez-Brizuela, S. A. Rosales-Corral, C. R. Curiel-Ortega, F. Pacheco-Moisés, J. J. García

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5 Scopus citations

Abstract

Objective: To determine the β-amyloid precursor protein (βAPP) isoforms ratio as a risk factor for Alzheimer's Disease and to assess its relationship with demographic and genetic variables of the disease. Methods: Blood samples from 26 patients fulfilling NINCDS-ADRDA diagnostic criteria for AD and 46 healthy control subjects were collected for Western blotting for βAPP. A ratio of βAPP isoforms, in optical densities, between the upper band (130 Kd) and the lower bands (106-110 Kd) was obtained. Odds ratios were obtained to determine risk factor of this component. Results: βAPP ratio on AD subjects was lower than that of control subjects: 0.3662 ± 0.1891 vs. 0.6769 ± 0.1021 (mean ± SD, p < 0.05). A low βAPP ratio (< 0.6) showed an OR of 4.63 (95% CI 1.45-15.33). When onset of disease was taken into account, a βAPP ratio on EOAD subjects of 0.3965 ± 0.1916 was found vs. 0.3445 ± 0.1965 on LOAD subjects (p > 0.05). Conclusions: Altered βAPP isoforms is a high risk factor for Alzheimer's disease, although it has no influence on the time of onset of the disease.

Original language	English
Pages (from-to)	119-125
Number of pages	7
Journal	Disease Markers
Volume	22
Issue number	3
DOIs	https://doi.org/10.1155/2006/347502
State	Published - 2006
Externally published	Yes

Keywords

Alzheimer's Disease
Risk factor
β-Amyloid precursor protein

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Sánchez-González, V. J., Ortiz, G. G., Gallegos-Arreola, P., Macías-Islas, M. A., Arias-Merino, E. D., Loera-Castañeda, V., Martínez-Cano, E., Velázquez-Brizuela, I. E., Rosales-Corral, S. A., Curiel-Ortega, C. R., Pacheco-Moisés, F., & García, J. J. (2006). Altered β-amyloid precursor protein isoforms in Mexican Alzheimer's Disease patients. Disease Markers, 22(3), 119-125. https://doi.org/10.1155/2006/347502

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title = "Altered β-amyloid precursor protein isoforms in Mexican Alzheimer's Disease patients",

abstract = "Objective: To determine the β-amyloid precursor protein (βAPP) isoforms ratio as a risk factor for Alzheimer's Disease and to assess its relationship with demographic and genetic variables of the disease. Methods: Blood samples from 26 patients fulfilling NINCDS-ADRDA diagnostic criteria for AD and 46 healthy control subjects were collected for Western blotting for βAPP. A ratio of βAPP isoforms, in optical densities, between the upper band (130 Kd) and the lower bands (106-110 Kd) was obtained. Odds ratios were obtained to determine risk factor of this component. Results: βAPP ratio on AD subjects was lower than that of control subjects: 0.3662 ± 0.1891 vs. 0.6769 ± 0.1021 (mean ± SD, p < 0.05). A low βAPP ratio (< 0.6) showed an OR of 4.63 (95% CI 1.45-15.33). When onset of disease was taken into account, a βAPP ratio on EOAD subjects of 0.3965 ± 0.1916 was found vs. 0.3445 ± 0.1965 on LOAD subjects (p > 0.05). Conclusions: Altered βAPP isoforms is a high risk factor for Alzheimer's disease, although it has no influence on the time of onset of the disease.",

keywords = "Alzheimer's Disease, Risk factor, β-Amyloid precursor protein",

author = "S{\'a}nchez-Gonz{\'a}lez, {V. J.} and Ortiz, {G. G.} and P. Gallegos-Arreola and Mac{\'i}as-Islas, {M. A.} and Arias-Merino, {E. D.} and V. Loera-Casta{\~n}eda and E. Mart{\'i}nez-Cano and Vel{\'a}zquez-Brizuela, {I. E.} and Rosales-Corral, {S. A.} and Curiel-Ortega, {C. R.} and F. Pacheco-Mois{\'e}s and Garc{\'i}a, {J. J.}",

year = "2006",

doi = "10.1155/2006/347502",

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Sánchez-González, VJ, Ortiz, GG, Gallegos-Arreola, P, Macías-Islas, MA, Arias-Merino, ED, Loera-Castañeda, V, Martínez-Cano, E, Velázquez-Brizuela, IE, Rosales-Corral, SA, Curiel-Ortega, CR, Pacheco-Moisés, F & García, JJ 2006, 'Altered β-amyloid precursor protein isoforms in Mexican Alzheimer's Disease patients', Disease Markers, vol. 22, no. 3, pp. 119-125. https://doi.org/10.1155/2006/347502

TY - JOUR

T1 - Altered β-amyloid precursor protein isoforms in Mexican Alzheimer's Disease patients

AU - Sánchez-González, V. J.

AU - Ortiz, G. G.

AU - Gallegos-Arreola, P.

AU - Macías-Islas, M. A.

AU - Arias-Merino, E. D.

AU - Loera-Castañeda, V.

AU - Martínez-Cano, E.

AU - Velázquez-Brizuela, I. E.

AU - Rosales-Corral, S. A.

AU - Curiel-Ortega, C. R.

AU - Pacheco-Moisés, F.

AU - García, J. J.

PY - 2006

Y1 - 2006

N2 - Objective: To determine the β-amyloid precursor protein (βAPP) isoforms ratio as a risk factor for Alzheimer's Disease and to assess its relationship with demographic and genetic variables of the disease. Methods: Blood samples from 26 patients fulfilling NINCDS-ADRDA diagnostic criteria for AD and 46 healthy control subjects were collected for Western blotting for βAPP. A ratio of βAPP isoforms, in optical densities, between the upper band (130 Kd) and the lower bands (106-110 Kd) was obtained. Odds ratios were obtained to determine risk factor of this component. Results: βAPP ratio on AD subjects was lower than that of control subjects: 0.3662 ± 0.1891 vs. 0.6769 ± 0.1021 (mean ± SD, p < 0.05). A low βAPP ratio (< 0.6) showed an OR of 4.63 (95% CI 1.45-15.33). When onset of disease was taken into account, a βAPP ratio on EOAD subjects of 0.3965 ± 0.1916 was found vs. 0.3445 ± 0.1965 on LOAD subjects (p > 0.05). Conclusions: Altered βAPP isoforms is a high risk factor for Alzheimer's disease, although it has no influence on the time of onset of the disease.

AB - Objective: To determine the β-amyloid precursor protein (βAPP) isoforms ratio as a risk factor for Alzheimer's Disease and to assess its relationship with demographic and genetic variables of the disease. Methods: Blood samples from 26 patients fulfilling NINCDS-ADRDA diagnostic criteria for AD and 46 healthy control subjects were collected for Western blotting for βAPP. A ratio of βAPP isoforms, in optical densities, between the upper band (130 Kd) and the lower bands (106-110 Kd) was obtained. Odds ratios were obtained to determine risk factor of this component. Results: βAPP ratio on AD subjects was lower than that of control subjects: 0.3662 ± 0.1891 vs. 0.6769 ± 0.1021 (mean ± SD, p < 0.05). A low βAPP ratio (< 0.6) showed an OR of 4.63 (95% CI 1.45-15.33). When onset of disease was taken into account, a βAPP ratio on EOAD subjects of 0.3965 ± 0.1916 was found vs. 0.3445 ± 0.1965 on LOAD subjects (p > 0.05). Conclusions: Altered βAPP isoforms is a high risk factor for Alzheimer's disease, although it has no influence on the time of onset of the disease.

KW - Alzheimer's Disease

KW - Risk factor

KW - β-Amyloid precursor protein

UR - http://www.scopus.com/inward/record.url?scp=33745126269&partnerID=8YFLogxK

U2 - 10.1155/2006/347502

DO - 10.1155/2006/347502

M3 - Artículo

C2 - 16788245

AN - SCOPUS:33745126269

SN - 0278-0240

VL - 22

SP - 119

EP - 125

JO - Disease Markers

JF - Disease Markers

IS - 3

ER -

Altered β-amyloid precursor protein isoforms in Mexican Alzheimer's Disease patients

Abstract

Keywords

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