Alteration in bilirubin excretion in individuals chronically exposed to arsenic in Mexico

Araceli Hernández-Zavala; Luz M. Del Razo; Carolina Aguilar; Gonzalo G. García-Vargas; Victor H. Borja; Mariano E. Cebrián

doi:10.1016/S0378-4274(98)00115-5

Alteration in bilirubin excretion in individuals chronically exposed to arsenic in Mexico

Araceli Hernández-Zavala, Luz M. Del Razo, Carolina Aguilar, Gonzalo G. García-Vargas, Victor H. Borja, Mariano E. Cebrián

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32 Scopus citations

Abstract

We have studied hepatic function in individuals chronically exposed to arsenic (As) via drinking water in Region Lagunera, Mexico. We studied 51 individuals living in three villages exposed to As in water. Nazareno (0.014 mgAs/l), Santa Ana (0.1 mgAs/l) and Benito Juarez (0.3 mgAs/l). We determined the serum activity of aspartate aminotransferase (SAT) and alanine aminotransferase (ALT) as indicators of hepatocellular injury and that of gamma-glutamyl-transpeptidase (GGT) and alkaline phosphatase (ALP) as indicators of cholestasic injury. Serum bilirubin was used as an indicator of organic conjugated anion transport. Total proteins, albumin and globulin fraction in serum were used as indicators of biosynthetic liver capacity. The main findings of this study were the predominantly conjugated hyperbilirubinemia and increased serum ALP activity which were related to the concentration of total arsenic (TAs) in urine, suggesting the presence of cholestasis in As-exposed individuals. No significant changes were observed in the other parameters studied. Copyright (C) 1998 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	79-84
Number of pages	6
Journal	Toxicology Letters
Volume	99
Issue number	2
DOIs	https://doi.org/10.1016/S0378-4274(98)00115-5
State	Published - 15 Oct 1998
Externally published	Yes

Keywords

Arsenic
Bilirubin and alanine aminotransferase
Chronic exposure
Conjugated hyperbilirubinemia

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10.1016/S0378-4274(98)00115-5

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title = "Alteration in bilirubin excretion in individuals chronically exposed to arsenic in Mexico",

abstract = "We have studied hepatic function in individuals chronically exposed to arsenic (As) via drinking water in Region Lagunera, Mexico. We studied 51 individuals living in three villages exposed to As in water. Nazareno (0.014 mgAs/l), Santa Ana (0.1 mgAs/l) and Benito Juarez (0.3 mgAs/l). We determined the serum activity of aspartate aminotransferase (SAT) and alanine aminotransferase (ALT) as indicators of hepatocellular injury and that of gamma-glutamyl-transpeptidase (GGT) and alkaline phosphatase (ALP) as indicators of cholestasic injury. Serum bilirubin was used as an indicator of organic conjugated anion transport. Total proteins, albumin and globulin fraction in serum were used as indicators of biosynthetic liver capacity. The main findings of this study were the predominantly conjugated hyperbilirubinemia and increased serum ALP activity which were related to the concentration of total arsenic (TAs) in urine, suggesting the presence of cholestasis in As-exposed individuals. No significant changes were observed in the other parameters studied. Copyright (C) 1998 Elsevier Science Ireland Ltd.",

keywords = "Arsenic, Bilirubin and alanine aminotransferase, Chronic exposure, Conjugated hyperbilirubinemia",

author = "Araceli Hern{\'a}ndez-Zavala and {M. Del Razo}, Luz and Carolina Aguilar and {G. Garc{\'i}a-Vargas}, Gonzalo and {H. Borja}, Victor and {E. Cebri{\'a}n}, Mariano",

note = "Funding Information: This work was partially supported by Consejo Nacional de Ciencia y Tecnolog{\'ı}a, M{\'e}xico (CONACYT 0576P-M)",

year = "1998",

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doi = "10.1016/S0378-4274(98)00115-5",

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T1 - Alteration in bilirubin excretion in individuals chronically exposed to arsenic in Mexico

AU - Hernández-Zavala, Araceli

AU - M. Del Razo, Luz

AU - Aguilar, Carolina

AU - G. García-Vargas, Gonzalo

AU - H. Borja, Victor

AU - E. Cebrián, Mariano

N1 - Funding Information: This work was partially supported by Consejo Nacional de Ciencia y Tecnologı́a, México (CONACYT 0576P-M)

PY - 1998/10/15

Y1 - 1998/10/15

N2 - We have studied hepatic function in individuals chronically exposed to arsenic (As) via drinking water in Region Lagunera, Mexico. We studied 51 individuals living in three villages exposed to As in water. Nazareno (0.014 mgAs/l), Santa Ana (0.1 mgAs/l) and Benito Juarez (0.3 mgAs/l). We determined the serum activity of aspartate aminotransferase (SAT) and alanine aminotransferase (ALT) as indicators of hepatocellular injury and that of gamma-glutamyl-transpeptidase (GGT) and alkaline phosphatase (ALP) as indicators of cholestasic injury. Serum bilirubin was used as an indicator of organic conjugated anion transport. Total proteins, albumin and globulin fraction in serum were used as indicators of biosynthetic liver capacity. The main findings of this study were the predominantly conjugated hyperbilirubinemia and increased serum ALP activity which were related to the concentration of total arsenic (TAs) in urine, suggesting the presence of cholestasis in As-exposed individuals. No significant changes were observed in the other parameters studied. Copyright (C) 1998 Elsevier Science Ireland Ltd.

AB - We have studied hepatic function in individuals chronically exposed to arsenic (As) via drinking water in Region Lagunera, Mexico. We studied 51 individuals living in three villages exposed to As in water. Nazareno (0.014 mgAs/l), Santa Ana (0.1 mgAs/l) and Benito Juarez (0.3 mgAs/l). We determined the serum activity of aspartate aminotransferase (SAT) and alanine aminotransferase (ALT) as indicators of hepatocellular injury and that of gamma-glutamyl-transpeptidase (GGT) and alkaline phosphatase (ALP) as indicators of cholestasic injury. Serum bilirubin was used as an indicator of organic conjugated anion transport. Total proteins, albumin and globulin fraction in serum were used as indicators of biosynthetic liver capacity. The main findings of this study were the predominantly conjugated hyperbilirubinemia and increased serum ALP activity which were related to the concentration of total arsenic (TAs) in urine, suggesting the presence of cholestasis in As-exposed individuals. No significant changes were observed in the other parameters studied. Copyright (C) 1998 Elsevier Science Ireland Ltd.

KW - Arsenic

KW - Bilirubin and alanine aminotransferase

KW - Chronic exposure

KW - Conjugated hyperbilirubinemia

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U2 - 10.1016/S0378-4274(98)00115-5

DO - 10.1016/S0378-4274(98)00115-5

M3 - Artículo

SN - 0378-4274

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JO - Toxicology Letters

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ER -

Alteration in bilirubin excretion in individuals chronically exposed to arsenic in Mexico

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Keywords

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