Albendazole and its derivative JVG9 induce encystation on Giardia intestinalis trophozoites

Armando Pérez-Rangel; José Manuel Hernández; Araceli Castillo-Romero; Lilián Yépez-Mulia; Rafael Castillo; Francisco Hernández-Luis; Benjamín Nogueda-Torres; Juan Pedro Luna-Arias; Gerardo Radilla; Gloria León-Avila

doi:10.1007/s00436-013-3521-1

Albendazole and its derivative JVG9 induce encystation on Giardia intestinalis trophozoites

Armando Pérez-Rangel, José Manuel Hernández, Araceli Castillo-Romero, Lilián Yépez-Mulia, Rafael Castillo, Francisco Hernández-Luis, Benjamín Nogueda-Torres, Juan Pedro Luna-Arias, Gerardo Radilla, Gloria León-Avila

Escuela Nacional de Ciencias Biológicas (ENCB)

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

In the present study, we evaluated the effect of an albendazole (ABZ) derivative JVG9 on cultured Giardia intestinalis. To assess the JVG9 effects, we evaluated the tubulin cytoskeleton by confocal microscopy, and we found that the characteristic staining was modified. The scanning electron microscopy images revealed extremely damaged trophozoites and cyst-like cells. The confocal images revealed that this drug triggered the expression of cyst wall protein 1 and encystation. We also found that at low doses, AL triggered the encystation process too.

Original language	English
Pages (from-to)	3251-3257
Number of pages	7
Journal	Parasitology Research
Volume	112
Issue number	9
DOIs	https://doi.org/10.1007/s00436-013-3521-1
State	Published - Sep 2013

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@article{f1a6235428df4a93a4bb0672814ecd7e,

title = "Albendazole and its derivative JVG9 induce encystation on Giardia intestinalis trophozoites",

abstract = "In the present study, we evaluated the effect of an albendazole (ABZ) derivative JVG9 on cultured Giardia intestinalis. To assess the JVG9 effects, we evaluated the tubulin cytoskeleton by confocal microscopy, and we found that the characteristic staining was modified. The scanning electron microscopy images revealed extremely damaged trophozoites and cyst-like cells. The confocal images revealed that this drug triggered the expression of cyst wall protein 1 and encystation. We also found that at low doses, AL triggered the encystation process too.",

author = "Armando P{\'e}rez-Rangel and Hern{\'a}ndez, {Jos{\'e} Manuel} and Araceli Castillo-Romero and Lili{\'a}n Y{\'e}pez-Mulia and Rafael Castillo and Francisco Hern{\'a}ndez-Luis and Benjam{\'i}n Nogueda-Torres and Luna-Arias, {Juan Pedro} and Gerardo Radilla and Gloria Le{\'o}n-Avila",

note = "Funding Information: Acknowledgments The authors thank the Electron Microscopy Unit of CINVESTAV for all the facilities. This investigation was supported by grants SIP2010726, SIP20110886, SIP20121394, SIP20130645, CONACyT 167376, and ICyTDF scholarships granted to P{\'e}rez-Rangel and Castillo-Romero.",

year = "2013",

month = sep,

doi = "10.1007/s00436-013-3521-1",

language = "Ingl{\'e}s",

volume = "112",

pages = "3251--3257",

journal = "Parasitology Research",

issn = "0932-0113",

number = "9",

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TY - JOUR

T1 - Albendazole and its derivative JVG9 induce encystation on Giardia intestinalis trophozoites

AU - Pérez-Rangel, Armando

AU - Hernández, José Manuel

AU - Castillo-Romero, Araceli

AU - Yépez-Mulia, Lilián

AU - Castillo, Rafael

AU - Hernández-Luis, Francisco

AU - Nogueda-Torres, Benjamín

AU - Luna-Arias, Juan Pedro

AU - Radilla, Gerardo

AU - León-Avila, Gloria

N1 - Funding Information: Acknowledgments The authors thank the Electron Microscopy Unit of CINVESTAV for all the facilities. This investigation was supported by grants SIP2010726, SIP20110886, SIP20121394, SIP20130645, CONACyT 167376, and ICyTDF scholarships granted to Pérez-Rangel and Castillo-Romero.

PY - 2013/9

Y1 - 2013/9

N2 - In the present study, we evaluated the effect of an albendazole (ABZ) derivative JVG9 on cultured Giardia intestinalis. To assess the JVG9 effects, we evaluated the tubulin cytoskeleton by confocal microscopy, and we found that the characteristic staining was modified. The scanning electron microscopy images revealed extremely damaged trophozoites and cyst-like cells. The confocal images revealed that this drug triggered the expression of cyst wall protein 1 and encystation. We also found that at low doses, AL triggered the encystation process too.

AB - In the present study, we evaluated the effect of an albendazole (ABZ) derivative JVG9 on cultured Giardia intestinalis. To assess the JVG9 effects, we evaluated the tubulin cytoskeleton by confocal microscopy, and we found that the characteristic staining was modified. The scanning electron microscopy images revealed extremely damaged trophozoites and cyst-like cells. The confocal images revealed that this drug triggered the expression of cyst wall protein 1 and encystation. We also found that at low doses, AL triggered the encystation process too.

UR - http://www.scopus.com/inward/record.url?scp=84882731006&partnerID=8YFLogxK

U2 - 10.1007/s00436-013-3521-1

DO - 10.1007/s00436-013-3521-1

M3 - Artículo

C2 - 23857298

SN - 0932-0113

VL - 112

SP - 3251

EP - 3257

JO - Parasitology Research

JF - Parasitology Research

IS - 9

ER -

Albendazole and its derivative JVG9 induce encystation on Giardia intestinalis trophozoites

Abstract

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