Adrenaline anorexia blocked by alpha and beta adrenergic antagonists in 24-h fasted rats

F. De-la-Cruz, M. L. Soto-Mora, T. Uriostegui, M. Russek

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of alpha and beta adrenergic blockers, phentolamine (PH) and propranolol (PR), on the anorexia induced by intraperitoneal (i.p.) adrenaline (A) was studied in 24 h-fasting male and female adult Wistar rats. I.p. PH elicited a small but significant increase in food intake in both males and females. The combination of PH + PR completely blocked the anorexia elicited by i.p. A in both males and females. In females, PH and PR alone partially blocked A-induced anorexia. In males, PH had no significant effect on A-induced anorexia but PR blocked it completely. It was concluded that the relative participation of alpha and beta adrenergic receptors in A-induced anorexia seems to depend on the sex of the rat, at least for the doses used in the present study: in females, alpha and beta actions seem to be approximately equal, while in males the beta is predominant. © 1990.
Original languageAmerican English
Pages (from-to)145-148
Number of pages130
JournalBehavioural Brain Research
DOIs
StatePublished - 5 Mar 1990

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Adrenergic alpha-Antagonists
Adrenergic beta-Antagonists
Phentolamine
Anorexia
Epinephrine
Propranolol
Receptors, Adrenergic, alpha
Receptors, Adrenergic, beta
Wistar Rats
Fasting
Eating

Cite this

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title = "Adrenaline anorexia blocked by alpha and beta adrenergic antagonists in 24-h fasted rats",
abstract = "The effect of alpha and beta adrenergic blockers, phentolamine (PH) and propranolol (PR), on the anorexia induced by intraperitoneal (i.p.) adrenaline (A) was studied in 24 h-fasting male and female adult Wistar rats. I.p. PH elicited a small but significant increase in food intake in both males and females. The combination of PH + PR completely blocked the anorexia elicited by i.p. A in both males and females. In females, PH and PR alone partially blocked A-induced anorexia. In males, PH had no significant effect on A-induced anorexia but PR blocked it completely. It was concluded that the relative participation of alpha and beta adrenergic receptors in A-induced anorexia seems to depend on the sex of the rat, at least for the doses used in the present study: in females, alpha and beta actions seem to be approximately equal, while in males the beta is predominant. {\circledC} 1990.",
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Adrenaline anorexia blocked by alpha and beta adrenergic antagonists in 24-h fasted rats. / De-la-Cruz, F.; Soto-Mora, M. L.; Uriostegui, T.; Russek, M.

In: Behavioural Brain Research, 05.03.1990, p. 145-148.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Adrenaline anorexia blocked by alpha and beta adrenergic antagonists in 24-h fasted rats

AU - De-la-Cruz, F.

AU - Soto-Mora, M. L.

AU - Uriostegui, T.

AU - Russek, M.

PY - 1990/3/5

Y1 - 1990/3/5

N2 - The effect of alpha and beta adrenergic blockers, phentolamine (PH) and propranolol (PR), on the anorexia induced by intraperitoneal (i.p.) adrenaline (A) was studied in 24 h-fasting male and female adult Wistar rats. I.p. PH elicited a small but significant increase in food intake in both males and females. The combination of PH + PR completely blocked the anorexia elicited by i.p. A in both males and females. In females, PH and PR alone partially blocked A-induced anorexia. In males, PH had no significant effect on A-induced anorexia but PR blocked it completely. It was concluded that the relative participation of alpha and beta adrenergic receptors in A-induced anorexia seems to depend on the sex of the rat, at least for the doses used in the present study: in females, alpha and beta actions seem to be approximately equal, while in males the beta is predominant. © 1990.

AB - The effect of alpha and beta adrenergic blockers, phentolamine (PH) and propranolol (PR), on the anorexia induced by intraperitoneal (i.p.) adrenaline (A) was studied in 24 h-fasting male and female adult Wistar rats. I.p. PH elicited a small but significant increase in food intake in both males and females. The combination of PH + PR completely blocked the anorexia elicited by i.p. A in both males and females. In females, PH and PR alone partially blocked A-induced anorexia. In males, PH had no significant effect on A-induced anorexia but PR blocked it completely. It was concluded that the relative participation of alpha and beta adrenergic receptors in A-induced anorexia seems to depend on the sex of the rat, at least for the doses used in the present study: in females, alpha and beta actions seem to be approximately equal, while in males the beta is predominant. © 1990.

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