Adrenaline anorexia blocked by alpha and beta adrenergic antagonists in 24-h fasted rats

F. De-la-Cruz; M. L. Soto-Mora; T. Uriostegui; M. Russek

doi:10.1016/0166-4328(90)90089-W

Adrenaline anorexia blocked by alpha and beta adrenergic antagonists in 24-h fasted rats

F. De-la-Cruz, M. L. Soto-Mora, T. Uriostegui, M. Russek

Escuela Nacional de Ciencias Biológicas (ENCB)

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The effect of alpha and beta adrenergic blockers, phentolamine (PH) and propranolol (PR), on the anorexia induced by intraperitoneal (i.p.) adrenaline (A) was studied in 24 h-fasting male and female adult Wistar rats. I.p. PH elicited a small but significant increase in food intake in both males and females. The combination of PH + PR completely blocked the anorexia elicited by i.p. A in both males and females. In females, PH and PR alone partially blocked A-induced anorexia. In males, PH had no significant effect on A-induced anorexia but PR blocked it completely. It was concluded that the relative participation of alpha and beta adrenergic receptors in A-induced anorexia seems to depend on the sex of the rat, at least for the doses used in the present study: in females, alpha and beta actions seem to be approximately equal, while in males the beta is predominant.

Original language	English
Pages (from-to)	145-148
Number of pages	4
Journal	Behavioural Brain Research
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/0166-4328(90)90089-W
State	Published - 5 Mar 1990

Keywords

Adrenaline
Anorexia
Phentolamine
Proparnolol

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title = "Adrenaline anorexia blocked by alpha and beta adrenergic antagonists in 24-h fasted rats",

abstract = "The effect of alpha and beta adrenergic blockers, phentolamine (PH) and propranolol (PR), on the anorexia induced by intraperitoneal (i.p.) adrenaline (A) was studied in 24 h-fasting male and female adult Wistar rats. I.p. PH elicited a small but significant increase in food intake in both males and females. The combination of PH + PR completely blocked the anorexia elicited by i.p. A in both males and females. In females, PH and PR alone partially blocked A-induced anorexia. In males, PH had no significant effect on A-induced anorexia but PR blocked it completely. It was concluded that the relative participation of alpha and beta adrenergic receptors in A-induced anorexia seems to depend on the sex of the rat, at least for the doses used in the present study: in females, alpha and beta actions seem to be approximately equal, while in males the beta is predominant.",

keywords = "Adrenaline, Anorexia, Phentolamine, Proparnolol",

author = "F. De-la-Cruz and Soto-Mora, {M. L.} and T. Uriostegui and M. Russek",

note = "Funding Information: This work was partially funded by Grant PCSABNA-022625 from the Consejo Nacional de Ciencia y Tecnologia (CONACYT).",

year = "1990",

month = mar,

day = "5",

doi = "10.1016/0166-4328(90)90089-W",

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AU - De-la-Cruz, F.

AU - Soto-Mora, M. L.

AU - Uriostegui, T.

AU - Russek, M.

N1 - Funding Information: This work was partially funded by Grant PCSABNA-022625 from the Consejo Nacional de Ciencia y Tecnologia (CONACYT).

PY - 1990/3/5

Y1 - 1990/3/5

N2 - The effect of alpha and beta adrenergic blockers, phentolamine (PH) and propranolol (PR), on the anorexia induced by intraperitoneal (i.p.) adrenaline (A) was studied in 24 h-fasting male and female adult Wistar rats. I.p. PH elicited a small but significant increase in food intake in both males and females. The combination of PH + PR completely blocked the anorexia elicited by i.p. A in both males and females. In females, PH and PR alone partially blocked A-induced anorexia. In males, PH had no significant effect on A-induced anorexia but PR blocked it completely. It was concluded that the relative participation of alpha and beta adrenergic receptors in A-induced anorexia seems to depend on the sex of the rat, at least for the doses used in the present study: in females, alpha and beta actions seem to be approximately equal, while in males the beta is predominant.

AB - The effect of alpha and beta adrenergic blockers, phentolamine (PH) and propranolol (PR), on the anorexia induced by intraperitoneal (i.p.) adrenaline (A) was studied in 24 h-fasting male and female adult Wistar rats. I.p. PH elicited a small but significant increase in food intake in both males and females. The combination of PH + PR completely blocked the anorexia elicited by i.p. A in both males and females. In females, PH and PR alone partially blocked A-induced anorexia. In males, PH had no significant effect on A-induced anorexia but PR blocked it completely. It was concluded that the relative participation of alpha and beta adrenergic receptors in A-induced anorexia seems to depend on the sex of the rat, at least for the doses used in the present study: in females, alpha and beta actions seem to be approximately equal, while in males the beta is predominant.

KW - Adrenaline

KW - Anorexia

KW - Phentolamine

KW - Proparnolol

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DO - 10.1016/0166-4328(90)90089-W

M3 - Artículo

SN - 0166-4328

VL - 37

SP - 145

EP - 148

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 2

ER -

Adrenaline anorexia blocked by alpha and beta adrenergic antagonists in 24-h fasted rats

Abstract

Keywords

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