Adjuvant treatment with a dialyzable leukocytes extract contributes to maintain HPV-infected women free of low-grade cervical lesions

Purpose of investigation: To investigate if adjuvant treatment with a dialyzable extract of leukocytes (DLE), may help HPV-infected patients with low-grade intraepithelial squamous cervical lesions (LIS) to get free of HPV infection and cervical lesions. Materials and Methods: Patients with untreated, low-grade cervical lesions were treated either with surgery (Group A) or with DLE (Group B). Patients with low-grade but recurrent cervical lesions were newly treated with surgery plus DLE (Group C). Results: A decreased or absent cervical lesion correlated with a diminished or absent HPV viral load at one year of treatment (r = 0.6, p < 0.05). Seventy-nine percent of Group B but only 50 % of Group C and 38 % of Group A patients were free of cervical lesion after 24 months of treatment (p < 0.05). Conclusion: The present data support the benefit of adding DLE as adjuvant for treating HPV-infected women with LIS.