Activity induced by two steroid-dihydropyrimidine derivatives on glucose levels in a diabetic rat model. relationship between descriptors logP and π and its Antidiabetic activity

In this work was designed to investigate the effects of two steroid-dihydropyrimidine derivatives on glucose levels in a rat diabetic model. Additionally, to delineate the structural chemical requirements of the dihydropyrimidine derivatives as antidiabetic agents; several parameters such as, the descriptors LogP and π were calculated. The results showed that dihydrotestosterone-dihydropyrimidine derivative significantly decrease the blood glucose levels at doses of 3.5 mg/dL (490 to 124 mg/dL; p = 0.06) and 7.0 mg/dL (466 to 81 mg/dL; p = 0.05) in comparison with progesteronedihydropyrimidine derivative at doses of 3.5 mg/dL (456 to 222 mg/dL; p = 0.05) and 7.0 mg/dL (487 to 232 mg/dL; p = 0.05). This phenomenon is conditioned mainly by the contribution of all substituent atoms involved in the chemical structure of the steroid derivatives which can induce several changes in both the lipofilicity and its activity on glucose levels.