TY - JOUR
T1 - Activity induced by a danazol derivative on perfusion pressure and coro-nary resistance in isolated rat heart
AU - Lauro, Figueroa Valverde
AU - Francisco, Díaz Cedillo
AU - Ma, Lopez Ramos
AU - Elodia, Garcia Cervera
PY - 2011/7
Y1 - 2011/7
N2 - Experimental studies suggest that danazol can be associated with changes in blood pressure. Nevertheless, there is scarce information about the effects of danazol and its derivatives at cardiovascular level. To clarify on this phenomenon, we evaluated the effects of danazol de-rivative on perfusion pressure in isolated rat heart using Langendorff flow model. Our re-sults demonstrated that pregnenolone-derivative (10-9 mM) significantly increase the perfu-sion pressure (p = 0.05) and vascular resistance (p = 0.05) in isolated heart. The activity in-duced by danazol derivative on perfusion pressure (10-9 to 10-4 mM) was blocked in presence of nifedipine (10-6 mM).These data suggest that activity induced by danazol derivative on perfusion pressure and vascular resistance is dependent upon its chemical structure. This phenomenon involves the L-type calcium channel activation through a non-genomic molecu-lar mechanism.
AB - Experimental studies suggest that danazol can be associated with changes in blood pressure. Nevertheless, there is scarce information about the effects of danazol and its derivatives at cardiovascular level. To clarify on this phenomenon, we evaluated the effects of danazol de-rivative on perfusion pressure in isolated rat heart using Langendorff flow model. Our re-sults demonstrated that pregnenolone-derivative (10-9 mM) significantly increase the perfu-sion pressure (p = 0.05) and vascular resistance (p = 0.05) in isolated heart. The activity in-duced by danazol derivative on perfusion pressure (10-9 to 10-4 mM) was blocked in presence of nifedipine (10-6 mM).These data suggest that activity induced by danazol derivative on perfusion pressure and vascular resistance is dependent upon its chemical structure. This phenomenon involves the L-type calcium channel activation through a non-genomic molecu-lar mechanism.
KW - Danazol
KW - Derivative
KW - Langendorff
KW - Perfusion pressure
UR - http://www.scopus.com/inward/record.url?scp=79960813075&partnerID=8YFLogxK
M3 - Artículo
SN - 0970-938X
VL - 22
SP - 289
EP - 294
JO - Biomedical Research (India)
JF - Biomedical Research (India)
IS - 3
ER -