Activity exerted by a testosterone derivative on myocardial injury using an ischemia/reperfusion model

Figueroa Valverde Lauro, Díaz Cedillo Francisco, García Cervera Elodia, Pool Gómez Eduardo, López Ramos Maria, Rosas Nexticapa Marcela, Hau Heredia Lenin, Sarabia Alcocer Betty, Velázquez Sarabia Betty Monica

Research output: Contribution to journalArticle

Abstract

Some reports indicate that several steroid derivatives have activity at cardiovascular level; nevertheless, there is scarce information about the activity exerted by the testosterone derivatives on cardiac injury caused by ischemia/reperfusion (I/R). Analyzing these data, in this study, a new testosterone derivative was synthetized with the objective of evaluating its effect on myocardial injury using an ischemia/reperfusion model. In addition, perfusion pressure and coronary resistance were evaluated in isolated rat hearts using the Langendorff technique. Additionally, molecular mechanism involved in the activity exerted by the testosterone derivative on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in the absence or presence of the following compounds: flutamide, prazosin, metoprolol, nifedipine, indomethacin, and PINANE TXA2. The results showed that the testosterone derivative significantly increases P = 0.05 the perfusion pressure and coronary resistance in isolated heart. Other data indicate that the testosterone derivative increases left ventricular pressure in a dose-dependent manner (0.001-100 nM); however, this phenomenon was significantly inhibited P = 0.06 by indomethacin and PINANE-TXA2P = 0.05 at a dose of 1 nM. In conclusion, these data suggest that testosterone derivative induces changes in the left ventricular pressure levels through thromboxane receptor activation. © 2014 Figueroa-Valverde Lauro et al.
Original languageAmerican English
JournalBioMed Research International
DOIs
StatePublished - 1 Jan 2014

Fingerprint

Reperfusion Injury
Testosterone
Derivatives
Ventricular Pressure
Perfusion
Pressure
Indomethacin
Thromboxane Receptors
Flutamide
Metoprolol
Prazosin
Nifedipine
Steroids
Rats
Chemical activation

Cite this

Lauro, Figueroa Valverde ; Francisco, Díaz Cedillo ; Elodia, García Cervera ; Eduardo, Pool Gómez ; Maria, López Ramos ; Marcela, Rosas Nexticapa ; Lenin, Hau Heredia ; Betty, Sarabia Alcocer ; Monica, Velázquez Sarabia Betty. / Activity exerted by a testosterone derivative on myocardial injury using an ischemia/reperfusion model. In: BioMed Research International. 2014.
@article{1601aea4a2f84fd3ad6ec0f3b22002dc,
title = "Activity exerted by a testosterone derivative on myocardial injury using an ischemia/reperfusion model",
abstract = "Some reports indicate that several steroid derivatives have activity at cardiovascular level; nevertheless, there is scarce information about the activity exerted by the testosterone derivatives on cardiac injury caused by ischemia/reperfusion (I/R). Analyzing these data, in this study, a new testosterone derivative was synthetized with the objective of evaluating its effect on myocardial injury using an ischemia/reperfusion model. In addition, perfusion pressure and coronary resistance were evaluated in isolated rat hearts using the Langendorff technique. Additionally, molecular mechanism involved in the activity exerted by the testosterone derivative on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in the absence or presence of the following compounds: flutamide, prazosin, metoprolol, nifedipine, indomethacin, and PINANE TXA2. The results showed that the testosterone derivative significantly increases P = 0.05 the perfusion pressure and coronary resistance in isolated heart. Other data indicate that the testosterone derivative increases left ventricular pressure in a dose-dependent manner (0.001-100 nM); however, this phenomenon was significantly inhibited P = 0.06 by indomethacin and PINANE-TXA2P = 0.05 at a dose of 1 nM. In conclusion, these data suggest that testosterone derivative induces changes in the left ventricular pressure levels through thromboxane receptor activation. {\circledC} 2014 Figueroa-Valverde Lauro et al.",
author = "Lauro, {Figueroa Valverde} and Francisco, {D{\'i}az Cedillo} and Elodia, {Garc{\'i}a Cervera} and Eduardo, {Pool G{\'o}mez} and Maria, {L{\'o}pez Ramos} and Marcela, {Rosas Nexticapa} and Lenin, {Hau Heredia} and Betty, {Sarabia Alcocer} and Monica, {Vel{\'a}zquez Sarabia Betty}",
year = "2014",
month = "1",
day = "1",
doi = "10.1155/2014/217865",
language = "American English",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

Activity exerted by a testosterone derivative on myocardial injury using an ischemia/reperfusion model. / Lauro, Figueroa Valverde; Francisco, Díaz Cedillo; Elodia, García Cervera; Eduardo, Pool Gómez; Maria, López Ramos; Marcela, Rosas Nexticapa; Lenin, Hau Heredia; Betty, Sarabia Alcocer; Monica, Velázquez Sarabia Betty.

In: BioMed Research International, 01.01.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Activity exerted by a testosterone derivative on myocardial injury using an ischemia/reperfusion model

AU - Lauro, Figueroa Valverde

AU - Francisco, Díaz Cedillo

AU - Elodia, García Cervera

AU - Eduardo, Pool Gómez

AU - Maria, López Ramos

AU - Marcela, Rosas Nexticapa

AU - Lenin, Hau Heredia

AU - Betty, Sarabia Alcocer

AU - Monica, Velázquez Sarabia Betty

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Some reports indicate that several steroid derivatives have activity at cardiovascular level; nevertheless, there is scarce information about the activity exerted by the testosterone derivatives on cardiac injury caused by ischemia/reperfusion (I/R). Analyzing these data, in this study, a new testosterone derivative was synthetized with the objective of evaluating its effect on myocardial injury using an ischemia/reperfusion model. In addition, perfusion pressure and coronary resistance were evaluated in isolated rat hearts using the Langendorff technique. Additionally, molecular mechanism involved in the activity exerted by the testosterone derivative on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in the absence or presence of the following compounds: flutamide, prazosin, metoprolol, nifedipine, indomethacin, and PINANE TXA2. The results showed that the testosterone derivative significantly increases P = 0.05 the perfusion pressure and coronary resistance in isolated heart. Other data indicate that the testosterone derivative increases left ventricular pressure in a dose-dependent manner (0.001-100 nM); however, this phenomenon was significantly inhibited P = 0.06 by indomethacin and PINANE-TXA2P = 0.05 at a dose of 1 nM. In conclusion, these data suggest that testosterone derivative induces changes in the left ventricular pressure levels through thromboxane receptor activation. © 2014 Figueroa-Valverde Lauro et al.

AB - Some reports indicate that several steroid derivatives have activity at cardiovascular level; nevertheless, there is scarce information about the activity exerted by the testosterone derivatives on cardiac injury caused by ischemia/reperfusion (I/R). Analyzing these data, in this study, a new testosterone derivative was synthetized with the objective of evaluating its effect on myocardial injury using an ischemia/reperfusion model. In addition, perfusion pressure and coronary resistance were evaluated in isolated rat hearts using the Langendorff technique. Additionally, molecular mechanism involved in the activity exerted by the testosterone derivative on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in the absence or presence of the following compounds: flutamide, prazosin, metoprolol, nifedipine, indomethacin, and PINANE TXA2. The results showed that the testosterone derivative significantly increases P = 0.05 the perfusion pressure and coronary resistance in isolated heart. Other data indicate that the testosterone derivative increases left ventricular pressure in a dose-dependent manner (0.001-100 nM); however, this phenomenon was significantly inhibited P = 0.06 by indomethacin and PINANE-TXA2P = 0.05 at a dose of 1 nM. In conclusion, these data suggest that testosterone derivative induces changes in the left ventricular pressure levels through thromboxane receptor activation. © 2014 Figueroa-Valverde Lauro et al.

U2 - 10.1155/2014/217865

DO - 10.1155/2014/217865

M3 - Article

C2 - 24839599

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

ER -