Activity exerted by a naphthalene-oxirane derivative on the ischemia/reperfusion injury

Figueroa Valverde Lauro, Hau Heredia Lenin, García Cervera Elodia, Pool Gómez Eduardo, López Ramos Maria, Vera Escobedo Maria Isabel, Díaz Cedillo Francisco, Rosas Nexticapa Marcela

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Abstract

© 2017, Scientific Publishers of India. All rights reserved. There are data, which indicate that myocardial ischemia/reperfusion injury is a serious problem involved on cardiovascular diseases. Some naphtalen-derivatives have been used as cardioprotective drugs on myocardial ischemia-reperfusion injury; however, their activity and the molecular mechanism involved on myocardial ischemia-reperfusion injury are very confusing. Therefore, the aim of this study was to evaluate the activity of a naphtalen-oxirane derivative on myocardial ischemia/reperfusion injury using an isolated heart model. Additionally, molecular mechanism involved in the activity exerted by the naphtalen-oxirane derivative on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in absence or presence of following compounds; prazosin, metoprolol, indomethacin and nifedipine. The results showed that the naphtalen-oxirane derivative reduce infarct size compared with the control conditions. Other results showed that the naphtalen-oxirane derivative significantly increases the perfusion pressure and coronary resistance in isolated heart in comparison the control. Finally, other data indicate that the naphtalen-oxirane derivative increase left ventricular pressure in a dose-dependent manner; however, this phenomenon was significantly inhibited by nifedipine. In conclusion, all these data suggest that the naphtalen-oxirane derivative exert a cardioprotective effect through calcium channels activation and consequently induce changes in the left ventricular pressure levels. This phenomenon results in decrease of myocardial necrosis after ischemia and reperfusion.
Original languageAmerican English
Pages (from-to)16-22
Number of pages13
JournalBiomedical Research (India)
StatePublished - 1 Jan 2017

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Lauro, F. V., Lenin, H. H., Elodia, G. C., Eduardo, P. G., Maria, L. R., Isabel, V. E. M., Francisco, D. C., & Marcela, R. N. (2017). Activity exerted by a naphthalene-oxirane derivative on the ischemia/reperfusion injury. Biomedical Research (India), 16-22.