TY - JOUR
T1 - Activity against drug resistant-tuberculosis strains of plants used in Mexican traditional medicine to treat tuberculosis and other respiratory diseases
AU - Camacho-Corona, María Del Rayo
AU - Ramírez-Cabrera, Mónica A.
AU - González-Santiago, Omar
AU - Garza-González, Elvira
AU - Palacios, Isidoro De Paz
AU - Luna-Herrera, Julieta
PY - 2008/1
Y1 - 2008/1
N2 - Tuberculosis (TB) kills about 3 million people per year worldwide. Furthermore, TB is an infectious disease associated with HIV patients, and there is a rise in multidrug-resistant TB (MDR-TB) cases around the world. There is a need for new anti-TB agents. The study evaluated the antimycobacterial activity of nine plants used in Mexican traditional medicine to treat tuberculosis and other respiratory diseases. Nasturtium officinale showed the best activity (MIC = 100 μg/mL) against the sensitive Mycobacterium tuberculosis. The following plants were active also but at 200 μg/mL: Citrus sinensis, Citrus aurantifolia, Foeniculum vulgare, Larrea tridentata, Musa acuminata and Olea europaea. Contrary to the above data, activity against drug-resistant variants of M. tuberculosis was more evident, e.g. N. officinale was the most potent (MIC ≤ 100 μg/mL) against the four mono-resistant variants tested; F. vulgare and O. europaea were active against all the resistant variants (MICs ≤ 100 μ/mL). The most susceptible variant was the isoniazid resistant, being inhibited by C. aurantifolia, C. sinensis and O. europaea (MIC = 25 μg/mL). These data point to the importance of biological testing of extracts against drug-resistant M. tuberculosis isolates, and the bioguided assay of these extracts for the identification of lead compounds against MDR-TB isolates.
AB - Tuberculosis (TB) kills about 3 million people per year worldwide. Furthermore, TB is an infectious disease associated with HIV patients, and there is a rise in multidrug-resistant TB (MDR-TB) cases around the world. There is a need for new anti-TB agents. The study evaluated the antimycobacterial activity of nine plants used in Mexican traditional medicine to treat tuberculosis and other respiratory diseases. Nasturtium officinale showed the best activity (MIC = 100 μg/mL) against the sensitive Mycobacterium tuberculosis. The following plants were active also but at 200 μg/mL: Citrus sinensis, Citrus aurantifolia, Foeniculum vulgare, Larrea tridentata, Musa acuminata and Olea europaea. Contrary to the above data, activity against drug-resistant variants of M. tuberculosis was more evident, e.g. N. officinale was the most potent (MIC ≤ 100 μg/mL) against the four mono-resistant variants tested; F. vulgare and O. europaea were active against all the resistant variants (MICs ≤ 100 μ/mL). The most susceptible variant was the isoniazid resistant, being inhibited by C. aurantifolia, C. sinensis and O. europaea (MIC = 25 μg/mL). These data point to the importance of biological testing of extracts against drug-resistant M. tuberculosis isolates, and the bioguided assay of these extracts for the identification of lead compounds against MDR-TB isolates.
KW - Antimycobacterial activity
KW - Mexican medicinal plants
KW - Mycobacterium tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=38549157559&partnerID=8YFLogxK
U2 - 10.1002/ptr.2269
DO - 10.1002/ptr.2269
M3 - Artículo
SN - 0951-418X
VL - 22
SP - 82
EP - 85
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 1
ER -