Acesulfame potassium: Its ecotoxicity measured through oxidative stress biomarkers in common carp (Cyprinus carpio)

Claudia Cruz-Rojas, Nely SanJuan-Reyes, María Paulina Aideé Gracia Fuentes-Benites, Octavio Dublan-García, Marcela Galar-Martínez, Hariz Islas-Flores, Leobardo Manuel Gómez-Oliván

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

© 2018 Elsevier B.V. Acesulfame potassium (ACS) is a widely-used sweetener worldwide. Its presence has been demonstrated in diverse bodies of water. However, the deleterious effects this causes in aquatic organisms has not yet been identified, which generates controversy concerning the risks that ACS represents after its disposal into the bodies of water. Thus, the objective of this work was to evaluate if the exposure of ACS in environmentally-relevant concentrations was capable of producing oxidative stress in blood, liver, gill, brain and muscle of common carp (Cyprinus carpio). With this finality, the carp were exposed to two environmentally-relevant concentrations (0.05 and 149 μg L −1 ) at different exposure times (12, 24, 48, 72 and 96 h), having controls in the same conditions for each exposure time. Posteriorly, the following biomarkers of damage were evaluated: hydroperoxide content (HPC), level of lipoperoxidation (LPX) and protein carbonyl content (PCC), as well as the activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). The results showed that ACS produces significant increase in damage biomarkers evaluated in all organs, mainly in gill, brain and muscle, as well as significant changes in the activity of antioxidant enzymes in the same organs. Thus, it is concluded that ACS is capable of producing oxidative stress in common carp (Cyprinus carpio).
Original languageAmerican English
Pages (from-to)772-784
Number of pages693
JournalScience of the Total Environment
DOIs
StatePublished - 10 Jan 2019

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Oxidative stress
Biomarkers
Potassium
biomarker
potassium
Antioxidants
antioxidant
Muscle
brain
Brain
muscle
Enzymes
enzyme
Aquatic organisms
Sweetening Agents
damage
Water
aquatic organism
Liver
Catalase

Cite this

Cruz-Rojas, C., SanJuan-Reyes, N., Fuentes-Benites, M. P. A. G., Dublan-García, O., Galar-Martínez, M., Islas-Flores, H., & Gómez-Oliván, L. M. (2019). Acesulfame potassium: Its ecotoxicity measured through oxidative stress biomarkers in common carp (Cyprinus carpio). Science of the Total Environment, 772-784. https://doi.org/10.1016/j.scitotenv.2018.08.034
Cruz-Rojas, Claudia ; SanJuan-Reyes, Nely ; Fuentes-Benites, María Paulina Aideé Gracia ; Dublan-García, Octavio ; Galar-Martínez, Marcela ; Islas-Flores, Hariz ; Gómez-Oliván, Leobardo Manuel. / Acesulfame potassium: Its ecotoxicity measured through oxidative stress biomarkers in common carp (Cyprinus carpio). In: Science of the Total Environment. 2019 ; pp. 772-784.
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Acesulfame potassium: Its ecotoxicity measured through oxidative stress biomarkers in common carp (Cyprinus carpio). / Cruz-Rojas, Claudia; SanJuan-Reyes, Nely; Fuentes-Benites, María Paulina Aideé Gracia; Dublan-García, Octavio; Galar-Martínez, Marcela; Islas-Flores, Hariz; Gómez-Oliván, Leobardo Manuel.

In: Science of the Total Environment, 10.01.2019, p. 772-784.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Acesulfame potassium: Its ecotoxicity measured through oxidative stress biomarkers in common carp (Cyprinus carpio)

AU - Cruz-Rojas, Claudia

AU - SanJuan-Reyes, Nely

AU - Fuentes-Benites, María Paulina Aideé Gracia

AU - Dublan-García, Octavio

AU - Galar-Martínez, Marcela

AU - Islas-Flores, Hariz

AU - Gómez-Oliván, Leobardo Manuel

PY - 2019/1/10

Y1 - 2019/1/10

N2 - © 2018 Elsevier B.V. Acesulfame potassium (ACS) is a widely-used sweetener worldwide. Its presence has been demonstrated in diverse bodies of water. However, the deleterious effects this causes in aquatic organisms has not yet been identified, which generates controversy concerning the risks that ACS represents after its disposal into the bodies of water. Thus, the objective of this work was to evaluate if the exposure of ACS in environmentally-relevant concentrations was capable of producing oxidative stress in blood, liver, gill, brain and muscle of common carp (Cyprinus carpio). With this finality, the carp were exposed to two environmentally-relevant concentrations (0.05 and 149 μg L −1 ) at different exposure times (12, 24, 48, 72 and 96 h), having controls in the same conditions for each exposure time. Posteriorly, the following biomarkers of damage were evaluated: hydroperoxide content (HPC), level of lipoperoxidation (LPX) and protein carbonyl content (PCC), as well as the activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). The results showed that ACS produces significant increase in damage biomarkers evaluated in all organs, mainly in gill, brain and muscle, as well as significant changes in the activity of antioxidant enzymes in the same organs. Thus, it is concluded that ACS is capable of producing oxidative stress in common carp (Cyprinus carpio).

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