TY - JOUR
T1 - Accelerated corneal collagen crosslinking
T2 - Technique, efficacy, safety, and applications
AU - Medeiros, Carla S.
AU - Giacomin, Natalia T.
AU - Bueno, Renata L.
AU - Ghanem, Ramon C.
AU - Moraes, Haroldo V.
AU - Santhiago, Marcony R.
N1 - Publisher Copyright:
© 2016 ASCRS and ESCRS
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Corneal collagen crosslinking (CXL) is an approach used to increase the biomechanical stability of the stromal tissue. Over the past 10 years, it has been used to halt the progression of ectatic diseases. According to the photochemical law of reciprocity, the same photochemical effect is achieved with reduced illumination time and correspondingly increased irradiation intensity. Several new CXL devices offer high ultraviolet-A irradiation intensity with different time settings. The main purpose of this review was to discuss the current use of different protocols of accelerated CXL and compare the efficacy and safety of accelerated CXL with the efficacy and safety of the established conventional method. Accelerated CXL proved to be safe and effective in halting progression of corneal ectasia. Corneal shape responses varied considerably, as did the demarcation line at different irradiance settings; the shorter the exposure time, the more superficial the demarcation line. Financial Disclosure Dr. Santhiago is a consultant to Ziemer Ophthalmic Systems AG and Alcon Laboratories, Inc. None of the authors has a financial or proprietary interest in any material or method mentioned.
AB - Corneal collagen crosslinking (CXL) is an approach used to increase the biomechanical stability of the stromal tissue. Over the past 10 years, it has been used to halt the progression of ectatic diseases. According to the photochemical law of reciprocity, the same photochemical effect is achieved with reduced illumination time and correspondingly increased irradiation intensity. Several new CXL devices offer high ultraviolet-A irradiation intensity with different time settings. The main purpose of this review was to discuss the current use of different protocols of accelerated CXL and compare the efficacy and safety of accelerated CXL with the efficacy and safety of the established conventional method. Accelerated CXL proved to be safe and effective in halting progression of corneal ectasia. Corneal shape responses varied considerably, as did the demarcation line at different irradiance settings; the shorter the exposure time, the more superficial the demarcation line. Financial Disclosure Dr. Santhiago is a consultant to Ziemer Ophthalmic Systems AG and Alcon Laboratories, Inc. None of the authors has a financial or proprietary interest in any material or method mentioned.
UR - http://www.scopus.com/inward/record.url?scp=85006823523&partnerID=8YFLogxK
U2 - 10.1016/j.jcrs.2016.11.028
DO - 10.1016/j.jcrs.2016.11.028
M3 - Artículo de revisión
SN - 0886-3350
VL - 42
SP - 1826
EP - 1835
JO - Journal of Cataract and Refractive Surgery
JF - Journal of Cataract and Refractive Surgery
IS - 12
ER -