TY - JOUR
T1 - Absorption peaks
T2 - α, β, γ and their covariance with age and hemoglobin in human blood samples using photoacoustic spectroscopy
AU - González-Domínguez, J. L.
AU - Hernández-Aguilar, C.
AU - Domínguez-Pacheco, F. A.
AU - Martínez-Ortiz, E.
AU - Cruz-Orea, A.
AU - Sánchez-Sinencio, F.
N1 - Funding Information:
Acknowledgments The authors gratefully thank the Social Security Mexican Institute for data and information provided. In particular, they show gratitude to Clinic No. 44 and to the Oncology Hospital. Special recognition is to be given to the Mexican agencies, CONACYT, ICyTDF, and the PIFI programme for their sponsorship. One of the authors (A. Cruz-Orea) is grateful for partial financial support from CONACYT Project No. 103632.
PY - 2012/11
Y1 - 2012/11
N2 - This study reports the absorption peaks α, β, γ in the Soret band of photoacoustic (PA) signals and their covariance with age and hemoglobin in human blood samples through PA spectroscopy. Samples were taken randomly from a masculine population grouped in three categories according to age: infants, young adults, and senior adults. Samples were prepared with two drops of blood from a 0.5 mL insulin syringe with a needle gauge 31G over 5 mm circles of filter paper. It was observed that the PA signal, the amplitude as a function of the wavelength, has a behavior as that reported for human blood for the three absorption peaks α, β, γ. In particular, the ratio γ/ β is due to electronic transitions associated with charge-transfer interactions of iron orbitals with the ligand states. Through an evaluation of optical absorption peaks in blood samples and their covariance with age and hemoglobin concentration, a relationship was found for the ratio peaks γ/ β and γ/ α with such parameters. Specifically, a negative covariance in the Soret band of the ratio peaks γ/ β and γ/ α with respect to both age and hemoglobin was found. This showed a tendency in their behavior. Further experiments of different populations may corroborate these conclusions.
AB - This study reports the absorption peaks α, β, γ in the Soret band of photoacoustic (PA) signals and their covariance with age and hemoglobin in human blood samples through PA spectroscopy. Samples were taken randomly from a masculine population grouped in three categories according to age: infants, young adults, and senior adults. Samples were prepared with two drops of blood from a 0.5 mL insulin syringe with a needle gauge 31G over 5 mm circles of filter paper. It was observed that the PA signal, the amplitude as a function of the wavelength, has a behavior as that reported for human blood for the three absorption peaks α, β, γ. In particular, the ratio γ/ β is due to electronic transitions associated with charge-transfer interactions of iron orbitals with the ligand states. Through an evaluation of optical absorption peaks in blood samples and their covariance with age and hemoglobin concentration, a relationship was found for the ratio peaks γ/ β and γ/ α with such parameters. Specifically, a negative covariance in the Soret band of the ratio peaks γ/ β and γ/ α with respect to both age and hemoglobin was found. This showed a tendency in their behavior. Further experiments of different populations may corroborate these conclusions.
KW - Absorption peaks
KW - Human blood
KW - Photoacoustic spectroscopy
KW - Soret band
UR - http://www.scopus.com/inward/record.url?scp=84888322450&partnerID=8YFLogxK
U2 - 10.1007/s10765-012-1304-z
DO - 10.1007/s10765-012-1304-z
M3 - Artículo
AN - SCOPUS:84888322450
SN - 0195-928X
VL - 33
SP - 1827
EP - 1833
JO - International Journal of Thermophysics
JF - International Journal of Thermophysics
IS - 10-11
ER -