Abnormality of adipokines and endothelial dysfunction in Mexican obese adolescents with insulin resistance

M. d.C. Ortiz Segura, Blanca Estela del Río Navarro, Benjamín Antonio Rodríguez Espino, Laurence A. Marchat, Fausto Sánchez Muñoz, Santiago Villafaña, Enrique Hong, Fabián Meza-Cuenca, Patrick Mailloux Salinas, Francisco Bolaños-Jiménez, Elena Zambrano, Abel Armando Arredondo-López, Guadalupe Bravo, Fengyang Huang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

© 2017 Taylor & Francis. Purpose: The aim of this study was to investigate the possible relationship among insulin resistance (IR), endothelial dysfunction, and alteration of adipokines in Mexican obese adolescents and their association with metabolic syndrome (MetS). Materials and methods: Two hundred and twenty-seven adolescents were classified according to the body mass index (BMI) (control: N=104; obese: N=123) and homeostasis model of the assessment-insulin resistance index (HOMA-IR) (obese with IR: N=65). The circulating concentrations of leptin, adiponectin, soluble intercellular adhesion molecule-1 (sICAM-1), and IR were determined by standard methods. Results: The obese adolescents with IR presented increased presence of MetS and higher circulating concentrations in sICAM-1 in comparison with the obese subjects without IR. The lowest concentrations of adiponectin were observed in the obese with IR. In multivariate linear regression models, sICAM-1 along with triglycerides, total cholesterol, and waist circumference was strongly associated with HOMA-IR (R2=0.457, P=0.008). Similarly, after adjustment for age, BMI-SDS, lipids, and adipokines, HOMA-IR remained associated with sICAM-1 (R2=0.372, P=0.008). BMI-SDS was mildly associated with leptin (R2=0.176, P=0.002) and the waist circumference was mild and independent determinant of adiponectin (R2=0.136, P=0.007). Conclusions: Our findings demonstrated that the obese adolescents, particularly the obese subjects with IR exhibited increased presence of MetS, abnormality of adipokines, and endothelial dysfunction. The significant interaction between IR and endothelial dysfunction may suggest a novel therapeutic approach to prevent or delay systemic IR and the genesis of cardiovascular diseases in obese patients.
Original languageAmerican English
Pages (from-to)252-259
Number of pages226
JournalEndocrine Research
DOIs
StatePublished - 3 Jul 2017

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Adipokines
Insulin Resistance
Intercellular Adhesion Molecule-1
Adiponectin
Body Mass Index
Homeostasis
Waist Circumference
Leptin
Linear Models
Triglycerides
Cardiovascular Diseases
Cholesterol

Cite this

Ortiz Segura, M. d.C. ; del Río Navarro, Blanca Estela ; Rodríguez Espino, Benjamín Antonio ; Marchat, Laurence A. ; Sánchez Muñoz, Fausto ; Villafaña, Santiago ; Hong, Enrique ; Meza-Cuenca, Fabián ; Mailloux Salinas, Patrick ; Bolaños-Jiménez, Francisco ; Zambrano, Elena ; Arredondo-López, Abel Armando ; Bravo, Guadalupe ; Huang, Fengyang. / Abnormality of adipokines and endothelial dysfunction in Mexican obese adolescents with insulin resistance. In: Endocrine Research. 2017 ; pp. 252-259.
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title = "Abnormality of adipokines and endothelial dysfunction in Mexican obese adolescents with insulin resistance",
abstract = "{\circledC} 2017 Taylor & Francis. Purpose: The aim of this study was to investigate the possible relationship among insulin resistance (IR), endothelial dysfunction, and alteration of adipokines in Mexican obese adolescents and their association with metabolic syndrome (MetS). Materials and methods: Two hundred and twenty-seven adolescents were classified according to the body mass index (BMI) (control: N=104; obese: N=123) and homeostasis model of the assessment-insulin resistance index (HOMA-IR) (obese with IR: N=65). The circulating concentrations of leptin, adiponectin, soluble intercellular adhesion molecule-1 (sICAM-1), and IR were determined by standard methods. Results: The obese adolescents with IR presented increased presence of MetS and higher circulating concentrations in sICAM-1 in comparison with the obese subjects without IR. The lowest concentrations of adiponectin were observed in the obese with IR. In multivariate linear regression models, sICAM-1 along with triglycerides, total cholesterol, and waist circumference was strongly associated with HOMA-IR (R2=0.457, P=0.008). Similarly, after adjustment for age, BMI-SDS, lipids, and adipokines, HOMA-IR remained associated with sICAM-1 (R2=0.372, P=0.008). BMI-SDS was mildly associated with leptin (R2=0.176, P=0.002) and the waist circumference was mild and independent determinant of adiponectin (R2=0.136, P=0.007). Conclusions: Our findings demonstrated that the obese adolescents, particularly the obese subjects with IR exhibited increased presence of MetS, abnormality of adipokines, and endothelial dysfunction. The significant interaction between IR and endothelial dysfunction may suggest a novel therapeutic approach to prevent or delay systemic IR and the genesis of cardiovascular diseases in obese patients.",
author = "{Ortiz Segura}, {M. d.C.} and {del R{\'i}o Navarro}, {Blanca Estela} and {Rodr{\'i}guez Espino}, {Benjam{\'i}n Antonio} and Marchat, {Laurence A.} and {S{\'a}nchez Mu{\~n}oz}, Fausto and Santiago Villafa{\~n}a and Enrique Hong and Fabi{\'a}n Meza-Cuenca and {Mailloux Salinas}, Patrick and Francisco Bola{\~n}os-Jim{\'e}nez and Elena Zambrano and Arredondo-L{\'o}pez, {Abel Armando} and Guadalupe Bravo and Fengyang Huang",
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Ortiz Segura, MDC, del Río Navarro, BE, Rodríguez Espino, BA, Marchat, LA, Sánchez Muñoz, F, Villafaña, S, Hong, E, Meza-Cuenca, F, Mailloux Salinas, P, Bolaños-Jiménez, F, Zambrano, E, Arredondo-López, AA, Bravo, G & Huang, F 2017, 'Abnormality of adipokines and endothelial dysfunction in Mexican obese adolescents with insulin resistance', Endocrine Research, pp. 252-259. https://doi.org/10.1080/07435800.2017.1294601

Abnormality of adipokines and endothelial dysfunction in Mexican obese adolescents with insulin resistance. / Ortiz Segura, M. d.C.; del Río Navarro, Blanca Estela; Rodríguez Espino, Benjamín Antonio; Marchat, Laurence A.; Sánchez Muñoz, Fausto; Villafaña, Santiago; Hong, Enrique; Meza-Cuenca, Fabián; Mailloux Salinas, Patrick; Bolaños-Jiménez, Francisco; Zambrano, Elena; Arredondo-López, Abel Armando; Bravo, Guadalupe; Huang, Fengyang.

In: Endocrine Research, 03.07.2017, p. 252-259.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Abnormality of adipokines and endothelial dysfunction in Mexican obese adolescents with insulin resistance

AU - Ortiz Segura, M. d.C.

AU - del Río Navarro, Blanca Estela

AU - Rodríguez Espino, Benjamín Antonio

AU - Marchat, Laurence A.

AU - Sánchez Muñoz, Fausto

AU - Villafaña, Santiago

AU - Hong, Enrique

AU - Meza-Cuenca, Fabián

AU - Mailloux Salinas, Patrick

AU - Bolaños-Jiménez, Francisco

AU - Zambrano, Elena

AU - Arredondo-López, Abel Armando

AU - Bravo, Guadalupe

AU - Huang, Fengyang

PY - 2017/7/3

Y1 - 2017/7/3

N2 - © 2017 Taylor & Francis. Purpose: The aim of this study was to investigate the possible relationship among insulin resistance (IR), endothelial dysfunction, and alteration of adipokines in Mexican obese adolescents and their association with metabolic syndrome (MetS). Materials and methods: Two hundred and twenty-seven adolescents were classified according to the body mass index (BMI) (control: N=104; obese: N=123) and homeostasis model of the assessment-insulin resistance index (HOMA-IR) (obese with IR: N=65). The circulating concentrations of leptin, adiponectin, soluble intercellular adhesion molecule-1 (sICAM-1), and IR were determined by standard methods. Results: The obese adolescents with IR presented increased presence of MetS and higher circulating concentrations in sICAM-1 in comparison with the obese subjects without IR. The lowest concentrations of adiponectin were observed in the obese with IR. In multivariate linear regression models, sICAM-1 along with triglycerides, total cholesterol, and waist circumference was strongly associated with HOMA-IR (R2=0.457, P=0.008). Similarly, after adjustment for age, BMI-SDS, lipids, and adipokines, HOMA-IR remained associated with sICAM-1 (R2=0.372, P=0.008). BMI-SDS was mildly associated with leptin (R2=0.176, P=0.002) and the waist circumference was mild and independent determinant of adiponectin (R2=0.136, P=0.007). Conclusions: Our findings demonstrated that the obese adolescents, particularly the obese subjects with IR exhibited increased presence of MetS, abnormality of adipokines, and endothelial dysfunction. The significant interaction between IR and endothelial dysfunction may suggest a novel therapeutic approach to prevent or delay systemic IR and the genesis of cardiovascular diseases in obese patients.

AB - © 2017 Taylor & Francis. Purpose: The aim of this study was to investigate the possible relationship among insulin resistance (IR), endothelial dysfunction, and alteration of adipokines in Mexican obese adolescents and their association with metabolic syndrome (MetS). Materials and methods: Two hundred and twenty-seven adolescents were classified according to the body mass index (BMI) (control: N=104; obese: N=123) and homeostasis model of the assessment-insulin resistance index (HOMA-IR) (obese with IR: N=65). The circulating concentrations of leptin, adiponectin, soluble intercellular adhesion molecule-1 (sICAM-1), and IR were determined by standard methods. Results: The obese adolescents with IR presented increased presence of MetS and higher circulating concentrations in sICAM-1 in comparison with the obese subjects without IR. The lowest concentrations of adiponectin were observed in the obese with IR. In multivariate linear regression models, sICAM-1 along with triglycerides, total cholesterol, and waist circumference was strongly associated with HOMA-IR (R2=0.457, P=0.008). Similarly, after adjustment for age, BMI-SDS, lipids, and adipokines, HOMA-IR remained associated with sICAM-1 (R2=0.372, P=0.008). BMI-SDS was mildly associated with leptin (R2=0.176, P=0.002) and the waist circumference was mild and independent determinant of adiponectin (R2=0.136, P=0.007). Conclusions: Our findings demonstrated that the obese adolescents, particularly the obese subjects with IR exhibited increased presence of MetS, abnormality of adipokines, and endothelial dysfunction. The significant interaction between IR and endothelial dysfunction may suggest a novel therapeutic approach to prevent or delay systemic IR and the genesis of cardiovascular diseases in obese patients.

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