A Novel Baker’s Yeast-Mediated Microwave-Induced Reduction of Racemic 3-Keto-2-Azetidinones: Facile Entry to Optically Active Hydroxy β-Lactam Derivatives

Aparna Das; Ram Naresh Yadav; Bimal Krishna Banik

doi:10.2174/2213337209666220126123630

A Novel Baker’s Yeast-Mediated Microwave-Induced Reduction of Racemic 3-Keto-2-Azetidinones: Facile Entry to Optically Active Hydroxy β-Lactam Derivatives

Aparna Das, Ram Naresh Yadav, Bimal Krishna Banik

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Objective: Microwave technology, together with enzymatic catalysis, is a nature-friend-ly chemical synthesis method with low wastage of solvent and a good yield of the products. Methods: Enzymes from various microorganisms can be used in the biochemical processes of a wide range of compounds assisted by microwave irradiation. Results: In this work, the microwave-induced reaction of α-keto β-lactams by Baker's yeast in organic solvent was conducted to afford optically active cis and trans-α-hydroxy-β-lactams for the first time. Conclusion: These hydroxy compounds are the precursors of numerous natural products of medicinal significance.

Original language	English
Pages (from-to)	195-198
Number of pages	4
Journal	Current Organocatalysis
Volume	9
Issue number	2
DOIs	https://doi.org/10.2174/2213337209666220126123630
State	Published - Jun 2022
Externally published	Yes

Keywords

Hydroxy β-lactams
baker’s yeast
microwave
optical activity
reduction
solvent

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10.2174/2213337209666220126123630

Cite this

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title = "A Novel Baker{\textquoteright}s Yeast-Mediated Microwave-Induced Reduction of Racemic 3-Keto-2-Azetidinones: Facile Entry to Optically Active Hydroxy β-Lactam Derivatives",

abstract = "Objective: Microwave technology, together with enzymatic catalysis, is a nature-friend-ly chemical synthesis method with low wastage of solvent and a good yield of the products. Methods: Enzymes from various microorganisms can be used in the biochemical processes of a wide range of compounds assisted by microwave irradiation. Results: In this work, the microwave-induced reaction of α-keto β-lactams by Baker's yeast in organic solvent was conducted to afford optically active cis and trans-α-hydroxy-β-lactams for the first time. Conclusion: These hydroxy compounds are the precursors of numerous natural products of medicinal significance.",

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AU - Yadav, Ram Naresh

AU - Banik, Bimal Krishna

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AB - Objective: Microwave technology, together with enzymatic catalysis, is a nature-friend-ly chemical synthesis method with low wastage of solvent and a good yield of the products. Methods: Enzymes from various microorganisms can be used in the biochemical processes of a wide range of compounds assisted by microwave irradiation. Results: In this work, the microwave-induced reaction of α-keto β-lactams by Baker's yeast in organic solvent was conducted to afford optically active cis and trans-α-hydroxy-β-lactams for the first time. Conclusion: These hydroxy compounds are the precursors of numerous natural products of medicinal significance.

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A Novel Baker’s Yeast-Mediated Microwave-Induced Reduction of Racemic 3-Keto-2-Azetidinones: Facile Entry to Optically Active Hydroxy β-Lactam Derivatives

Abstract

Keywords

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