TY - JOUR
T1 - A novel β-catenin signaling pathway activated by IL-1β leads to the onset of epithelial-mesenchymal transition in breast cancer cells
AU - Perez-Yepez, Eloy Andres
AU - Ayala-Sumuano, Jorge Tonatiuh
AU - Lezama, Ruth
AU - Meza, Isaura
N1 - Publisher Copyright:
© 2014 Elsevier Ireland Ltd.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Interleukin 1β has been associated with tumor development, invasiveness and metastasis in various types of cancer. However, the molecular mechanisms underlying this association have not been clearly elucidated. The present study is the first to show, in breast cancer cells, that an IL-1β/IL-1RI/β-catenin signaling pathway induces β-catenin accumulation due to GSK3β inactivation by Akt phosphorylation. Translocation to the nucleus of accumulated β-catenin and formation of the TCF/Lef/β-catenin complex induce sequential expression of c-MYC, CCDN1, SNAIL1 and MMP2, leading to up-regulation of proliferation, migration and invasion; all of the processes shown to be required, in cancerous cells, to initiate transition from a non-invading to an invasive phenotype.
AB - Interleukin 1β has been associated with tumor development, invasiveness and metastasis in various types of cancer. However, the molecular mechanisms underlying this association have not been clearly elucidated. The present study is the first to show, in breast cancer cells, that an IL-1β/IL-1RI/β-catenin signaling pathway induces β-catenin accumulation due to GSK3β inactivation by Akt phosphorylation. Translocation to the nucleus of accumulated β-catenin and formation of the TCF/Lef/β-catenin complex induce sequential expression of c-MYC, CCDN1, SNAIL1 and MMP2, leading to up-regulation of proliferation, migration and invasion; all of the processes shown to be required, in cancerous cells, to initiate transition from a non-invading to an invasive phenotype.
KW - Breast cancer cell
KW - IL-1RI/β-catenin signaling
KW - IL-1β stimulation
KW - Invasiveness
UR - http://www.scopus.com/inward/record.url?scp=84909990521&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2014.08.015
DO - 10.1016/j.canlet.2014.08.015
M3 - Artículo
C2 - 25135221
SN - 0304-3835
VL - 354
SP - 164
EP - 171
JO - Cancer Letters
JF - Cancer Letters
IS - 1
ER -