TY - JOUR
T1 - A microwave-assisted Bismuth nitrate-catalyzed unique route toward 1,4-dihydropyridines
AU - Bandyopadhyay, Debasish
AU - Maldonado, Stephanie
AU - Banik, Bimal K.
PY - 2012/3
Y1 - 2012/3
N2 - The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives. Bismuth nitrate pentahydrate under microwave irradiation is proven to act as a very efficient catalyst for a one-pot, three-component synthesis of 1,4-dihydropyridines in excellent yields from diverse amines/ammonium acetate, aldehydes and 1,3-dicarbonyl compounds within 1-3 min under solvent-free conditions. The present environmentally benign procedure for the synthesis of 1,4-dihydropyridines is suitable for library synthesis and it will find application in the synthesis of potent biologically active molecules. The excellent yield and extreme rapidity of the method is due to a concurrent effect of the catalyst and microwave irradiation.
AB - The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives. Bismuth nitrate pentahydrate under microwave irradiation is proven to act as a very efficient catalyst for a one-pot, three-component synthesis of 1,4-dihydropyridines in excellent yields from diverse amines/ammonium acetate, aldehydes and 1,3-dicarbonyl compounds within 1-3 min under solvent-free conditions. The present environmentally benign procedure for the synthesis of 1,4-dihydropyridines is suitable for library synthesis and it will find application in the synthesis of potent biologically active molecules. The excellent yield and extreme rapidity of the method is due to a concurrent effect of the catalyst and microwave irradiation.
KW - 1,4-Dihydropyridines
KW - Bismuth nitrate
KW - Catalysis
KW - Green synthesis
KW - Microwave
UR - http://www.scopus.com/inward/record.url?scp=84858964208&partnerID=8YFLogxK
U2 - 10.3390/molecules17032643
DO - 10.3390/molecules17032643
M3 - Artículo
SN - 1420-3049
VL - 17
SP - 2643
EP - 2662
JO - Molecules
JF - Molecules
IS - 3
ER -