TY - JOUR
T1 - A Key Metabolic Regulator of Bone and Cartilage Health
AU - Pérez-Hernández, Elizabeth
AU - Pastrana-Carballo, Jesús Javier
AU - Gómez-Chávez, Fernando
AU - Gupta, Ramesh C.
AU - Pérez-Hernández, Nury
N1 - Publisher Copyright:
Copyright © 2022 Korean Endocrine Society.
PY - 2022/8
Y1 - 2022/8
N2 - Taurine, a cysteine-derived zwitterionic sulfonic acid, is a common ingredient in energy drinks and is naturally found in fish and other seafood. In humans, taurine is produced mainly in the liver, and it can also be obtained from food. In target tissues, such as the retina, heart, and skeletal muscle, it functions as an essential antioxidant, osmolyte, and antiapoptotic agent. Taurine is also involved in energy metabolism and calcium homeostasis. Taurine plays a considerable role in bone growth and development, and high-profile reports have demonstrated the importance of its metabolism for bone health. However, these reports have not been collated for more than 10 years. Therefore, this review focuses on taurine–bone interactions and covers recently discovered aspects of taurine’s effects on osteoblastogenesis, osteoclastogenesis, bone structure, and bone pathologies (e.g., osteoporosis and fracture healing), with due attention to the taurine–cartilage relationship.
AB - Taurine, a cysteine-derived zwitterionic sulfonic acid, is a common ingredient in energy drinks and is naturally found in fish and other seafood. In humans, taurine is produced mainly in the liver, and it can also be obtained from food. In target tissues, such as the retina, heart, and skeletal muscle, it functions as an essential antioxidant, osmolyte, and antiapoptotic agent. Taurine is also involved in energy metabolism and calcium homeostasis. Taurine plays a considerable role in bone growth and development, and high-profile reports have demonstrated the importance of its metabolism for bone health. However, these reports have not been collated for more than 10 years. Therefore, this review focuses on taurine–bone interactions and covers recently discovered aspects of taurine’s effects on osteoblastogenesis, osteoclastogenesis, bone structure, and bone pathologies (e.g., osteoporosis and fracture healing), with due attention to the taurine–cartilage relationship.
KW - Cartilage
KW - Osteoarthritis
KW - Osteoblasts
KW - Osteoclasts
KW - Osteoporosis
KW - Taurine
UR - http://www.scopus.com/inward/record.url?scp=85142330647&partnerID=8YFLogxK
U2 - 10.3803/EnM.2022.1443
DO - 10.3803/EnM.2022.1443
M3 - Artículo de revisión
C2 - 35938304
AN - SCOPUS:85142330647
SN - 2093-596X
VL - 37
SP - 559
EP - 574
JO - Endocrinology and Metabolism
JF - Endocrinology and Metabolism
IS - 4
ER -