A convenient approach to the synthesis of the imidazo[5,1-b]oxazole ring system

Héctor Salgado-Zamora; Elena Campos; Rogelio Jiménez; Esmeralda Sánchez-Pavón; Humberto Cervantes

doi:10.3987/COM-98-S(H)52

A convenient approach to the synthesis of the imidazo[5,1-b]oxazole ring system

Héctor Salgado-Zamora, Elena Campos, Rogelio Jiménez, Esmeralda Sánchez-Pavón, Humberto Cervantes

Escuela Nacional de Ciencias Biológicas (ENCB)

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Reaction of 4(5)-bromo-2-methyl-5(4)-nitroimidazole with phenacyl bromide derivatives led to 4-bromo-2-methyl-1-phenacyl-5-nitro- and 5-bromo- 2-methyl-1-phenacyl-4-nitroimidazoles. Treatment of the latter isomers with potassium tert-butoxide in dry THF yielded imidazo[5,1-b]oxazoles.

Original language	English
Pages (from-to)	1081-1090
Number of pages	10
Journal	Heterocycles
Volume	50
Issue number	2
DOIs	https://doi.org/10.3987/COM-98-S(H)52
State	Published - 1 Apr 1999

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title = "A convenient approach to the synthesis of the imidazo[5,1-b]oxazole ring system",

abstract = "Reaction of 4(5)-bromo-2-methyl-5(4)-nitroimidazole with phenacyl bromide derivatives led to 4-bromo-2-methyl-1-phenacyl-5-nitro- and 5-bromo- 2-methyl-1-phenacyl-4-nitroimidazoles. Treatment of the latter isomers with potassium tert-butoxide in dry THF yielded imidazo[5,1-b]oxazoles.",

author = "H{\'e}ctor Salgado-Zamora and Elena Campos and Rogelio Jim{\'e}nez and Esmeralda S{\'a}nchez-Pav{\'o}n and Humberto Cervantes",

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T1 - A convenient approach to the synthesis of the imidazo[5,1-b]oxazole ring system

AU - Salgado-Zamora, Héctor

AU - Campos, Elena

AU - Jiménez, Rogelio

AU - Sánchez-Pavón, Esmeralda

AU - Cervantes, Humberto

PY - 1999/4/1

Y1 - 1999/4/1

N2 - Reaction of 4(5)-bromo-2-methyl-5(4)-nitroimidazole with phenacyl bromide derivatives led to 4-bromo-2-methyl-1-phenacyl-5-nitro- and 5-bromo- 2-methyl-1-phenacyl-4-nitroimidazoles. Treatment of the latter isomers with potassium tert-butoxide in dry THF yielded imidazo[5,1-b]oxazoles.

AB - Reaction of 4(5)-bromo-2-methyl-5(4)-nitroimidazole with phenacyl bromide derivatives led to 4-bromo-2-methyl-1-phenacyl-5-nitro- and 5-bromo- 2-methyl-1-phenacyl-4-nitroimidazoles. Treatment of the latter isomers with potassium tert-butoxide in dry THF yielded imidazo[5,1-b]oxazoles.

UR - http://www.scopus.com/inward/record.url?scp=0033117736&partnerID=8YFLogxK

U2 - 10.3987/COM-98-S(H)52

DO - 10.3987/COM-98-S(H)52

M3 - Artículo

SN - 0385-5414

VL - 50

SP - 1081

EP - 1090

JO - Heterocycles

JF - Heterocycles

IS - 2

ER -

A convenient approach to the synthesis of the imidazo[5,1-b]oxazole ring system

Abstract

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