TY - JOUR
T1 - 6-Hydroxydopamine lesion in thalamic reticular nucleus reduces anxiety behaviour in the rat
AU - Picazo, Ofir
AU - Chuc-Meza, Eliezer
AU - Anaya-Martinez, Veronica
AU - Jimenez, Ismael
AU - Aceves, Jorge
AU - Garcia-Ramirez, Martha
N1 - Funding Information:
The authors thank to Mr. Allan Larsen for checking the language and Valentina Ramirez Rosas and Arturo Sierra Sanchez for their excellent technical assistance. This study was partially supported by COFAA and SIP-IPN and a grant from Conacyt (50427Q) to J.A.
PY - 2009/2/11
Y1 - 2009/2/11
N2 - We have studied the effect of the lesion of the dopaminergic innervation of the thalamic reticular nucleus (TRn) on anxiety and motor behaviour. The lesion of the dopamine innervation was produced by the injection of 6-hydroxydopamine into the dorsal part of the thalamic reticular nucleus. The lesion decreased the number of TH (+) cells of the pars compacta of substantia nigra by 33%, without modifying the number of TH (+) cells in ventral tegmental area. The lesion increased the time spent by the rats on the open arms of the elevated plus maze and decreased the duration of burying in the shock-probe test. Both results suggest reduced anxiety. The loss of the dopamine innervation to the TRn decreased the number of rearings but did not significantly affect total motor activity, gait or motor coordination, as evidenced by rotarod performance. These findings suggest that dopamine in the TRn plays a role in fear-related behaviour.
AB - We have studied the effect of the lesion of the dopaminergic innervation of the thalamic reticular nucleus (TRn) on anxiety and motor behaviour. The lesion of the dopamine innervation was produced by the injection of 6-hydroxydopamine into the dorsal part of the thalamic reticular nucleus. The lesion decreased the number of TH (+) cells of the pars compacta of substantia nigra by 33%, without modifying the number of TH (+) cells in ventral tegmental area. The lesion increased the time spent by the rats on the open arms of the elevated plus maze and decreased the duration of burying in the shock-probe test. Both results suggest reduced anxiety. The loss of the dopamine innervation to the TRn decreased the number of rearings but did not significantly affect total motor activity, gait or motor coordination, as evidenced by rotarod performance. These findings suggest that dopamine in the TRn plays a role in fear-related behaviour.
KW - 6-Hydroxydopamine
KW - Anxiety
KW - Dopamine
KW - Motor activity
KW - Thalamic reticular nucleus
UR - http://www.scopus.com/inward/record.url?scp=58149345989&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2008.08.047
DO - 10.1016/j.bbr.2008.08.047
M3 - Artículo
C2 - 18824199
SN - 0166-4328
VL - 197
SP - 317
EP - 322
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 2
ER -