TY - JOUR
T1 - 1-Boc-Piperidine-4-Carboxaldehyde Prevents Binge-Eating Behaviour and Anxiety in Rats
AU - Guzmán-Rodríguez, Sergio
AU - Chávez-Reyes, Jesús
AU - Vázquez-León, Priscila
AU - Soriano-Ursuá, Marvin A.
AU - Rosalez, Melvin N.
AU - Allende, Gonzalo
AU - Marichal-Cancino, Bruno A.
N1 - Publisher Copyright:
© 2021 S. Karger AG, Basel.
PY - 2021/5
Y1 - 2021/5
N2 - Background: Piperidines are biogenic amines studied mainly in toxicology because they were initially found as alkaloids from peppers and insect venoms. Piperidines are also produced in the human body, and their actions seem to be related to wakefulness/sleep and other cognitive phenomena. Piperidines have been minimally characterized for therapeutic applications. In this context, 1-Boc-piperidine-4-carboxaldehyde (1-Boc-piperidine) is a piperidine-derivative molecule with no mechanism of action reported, although its uses include the synthesis of GPR119 selective agonists that have been patented as anti-obesity drugs. Objectives: The aim of this work was to study the effects of 1-Boc-piperidine on binge-eating behaviour and anxiety in Wistar rats. Methods: In experimental protocol 1, binge-eating behaviour was induced in animals that received pre-treatment (i.p.) with (i) vehicle (methanol 10%; 1 mL/kg), (ii) 1-Boc-piperidine (1 μmol kg-1), or (iii) 1-Boc-piperidine (10 μmol kg-1). In experimental protocol 2, mildly stressed animals were evaluated in the elevated plus maze under the acute effects of the pre-treatments applied in experimental protocol 1. Results and Conclusions: 1-Boc-piperidine decreased, in a dose-dependent manner, the intake of calories from a succulent hyper-caloric food in a binge-eating protocol in female rats, whereas the acute exposition to this piperidine exerted an anxiolytic effect in the male rat. In both effects, the mechanism of action remains to be characterized.
AB - Background: Piperidines are biogenic amines studied mainly in toxicology because they were initially found as alkaloids from peppers and insect venoms. Piperidines are also produced in the human body, and their actions seem to be related to wakefulness/sleep and other cognitive phenomena. Piperidines have been minimally characterized for therapeutic applications. In this context, 1-Boc-piperidine-4-carboxaldehyde (1-Boc-piperidine) is a piperidine-derivative molecule with no mechanism of action reported, although its uses include the synthesis of GPR119 selective agonists that have been patented as anti-obesity drugs. Objectives: The aim of this work was to study the effects of 1-Boc-piperidine on binge-eating behaviour and anxiety in Wistar rats. Methods: In experimental protocol 1, binge-eating behaviour was induced in animals that received pre-treatment (i.p.) with (i) vehicle (methanol 10%; 1 mL/kg), (ii) 1-Boc-piperidine (1 μmol kg-1), or (iii) 1-Boc-piperidine (10 μmol kg-1). In experimental protocol 2, mildly stressed animals were evaluated in the elevated plus maze under the acute effects of the pre-treatments applied in experimental protocol 1. Results and Conclusions: 1-Boc-piperidine decreased, in a dose-dependent manner, the intake of calories from a succulent hyper-caloric food in a binge-eating protocol in female rats, whereas the acute exposition to this piperidine exerted an anxiolytic effect in the male rat. In both effects, the mechanism of action remains to be characterized.
KW - 1-Boc-piperidine-4-carboxaldehyde
KW - Anxiety
KW - Binge-eating behaviour
KW - GPCRs
KW - Molecular modelling
KW - Piperidine derivatives
UR - http://www.scopus.com/inward/record.url?scp=85103236967&partnerID=8YFLogxK
U2 - 10.1159/000513376
DO - 10.1159/000513376
M3 - Artículo
C2 - 33756489
AN - SCOPUS:85103236967
SN - 0031-7012
VL - 106
SP - 305
EP - 315
JO - Pharmacology
JF - Pharmacology
IS - 5-6
ER -