1, 2, 4-triazoles clubbed pyrimidine compounds with synthesis, antimicrobial, antituberculosis, antimalarial, and anti-protozoal studies

Triazoles are famous as an antifungal agent. Itraconazole and fluconazole are the best examples of antifungal drugs available in the market, which consist of an active triazole moiety. Pyrimidines are also bioactive molecules which shows multiple bioactivity. It’s an effort to synthesize pyrimidine clubbed triazole to enhance bioactivity. To synthesize new active pyrimidine clubbed triazole biomolecule and to evaluate these new products for better drug potential as antimicrobial, antituberculosis, antimalarial, and anti-protozoal, N-[4-(substituted phenyl)-6-(substituted aryl) pyrimidine-2-yl]-2-[(4H-1,2,4-triazol-4-yl)amino]acetamide(3_A-J) were synthesized by different method such as cyclization, condensation, purification and crystallization. The newly synthesized compounds were characterized by IR,¹H NMR,¹³C NMR and mass spectral analysis and screened for antibacterial, antifungal, anti-tuberculosis, antimalarial, and antiprotozoal activities. These compounds satisfied the bioactive response and simple way for the synthesis.